micrornas (mirnas) are small preserved non-coding rna molecules that regulate gene expression post-transcriptionally by targeting the 3' utr of mrnas for translational repression or degradation. the rising evidence has established the significant role of mirnas within the regulation of immune system and the prevention of autoimmunity. mir-146a has obtained an importance as a modulator of d...

the effects of methanolic extract and leaf powder of artemisia annua were studied on performance, cellular and humoral immunity in 240 cobb broiler chicks in a completely randomized design. control group did not receive any treatment. the chicks in the second and third groups were fed with feed which contained 2000 and 4000 ppm plant extract in diet and in the groups 4, 5 and 6 chicks received ...

objectives: the aim of the present study was to investigate immunotoxic effect of safranal (saf), a main component of crocus sativus essential oil, using balb/c mice. materials and methods: saf was administered intraperitoneally at doses of 0.1, 0.5 and 1 ml/kg for 3 weeks. hystopathological examination of spleen and bone marrow, cellularity of spleen, delayed type of hypersensitivity (dth) res...

the plant-pathogen interaction is a multifactor process that may lead to resistance or susceptible responses of plant to pathogens. during the arms race between plant and pathogens, various biochemical, molecular and physiological events are triggered in plant cells such as ros signaling, hormone activation and gene expression reprogramming. in plants, micrornas (mirnas) are key post-transcript...

exposure to high dosages of sulfur mustard (sm) can cause bone marrow depression, immune system suppression, impairment of the immune functions, and eventually results in diseases due to secondary immune disorders. in this article, we have studied the effects of this poison on iranian veterans by analysis of related published studies. in a systematic search, the effects of sm gas on iranian vic...

objective: hypericum perforatum (st. john's wort) has long been used in traditional medicine to treat a variety of internal and external ailments. the present study was done to evaluate the immumodulatory potentials of the hydroalcoholic extract of h. perforatum. materials and methods: twenty male balb/c-mice were randomly allocated in two equal groups and immunized with sheep red blood ce...

objective: some evidence suggests that chronic uptake of estragole and methyl-eugenol, found in the essential oil of artemisia dracunculus (tarragon), may be associated with an increased risk of hepato-carcinogenicity. the present study was conducted to investigate the immumodulatory and anti-inflammatory potentials of estragole and methyl-eugenol free extract of tarragon. materials and methods...

objective(s) studies have described immunomedulatory effects of sun exposure and ultraviolet radiation on infectious and neoplastic diseases. here the effect of exposure to low potency radiation of sun on the course of leishmaniasis in mice was studied. materials and methods fifteen balb/c mice were exposed to suberythemogenic doses of sun (mean 180 mj/cm2/day of uvb) 2 months before and 4 mont...

background and objectives: brucellosis is an important health problem in developing countries and no vaccine is available for the prevention of infection in humans. because of clinically infectious diseases and their economic consequences in human and animals, designing a proper vaccine against brucella is desirable. in this study, we evaluated the immune responses induced by a designed recombi...

conclusions results indicated that the present vaccination program is insufficient for immunity against measles in this area. the general population immunity was lower than the necessary level for the elimination of measles. therefore, sero-epidemiological studies are necessary to organize national programs for control and elimination of measles. results overall, 821 (91.2%) of the studied popu...