Introduction: Extraosseous accumulation of 99mTc – methylene diphosphonate (MDP) may be due to neoplastic, dystrophic, hormonal, inflammatory, ischemic, traumatic or excretory disorders. 99mTc-MDP incidental thyroid uptake is not frequent and is possibly caused by the presence of dystrophic or metastatic calcification, biopsy procedure and presence of beni...

Bone scintigraphy with 99mTc diphosphonates may exhibit extraosseous lesions in addition to metastatic lesions. Multiple factors can affect extraosseous 99mTc methylene diphosphonate (MDP) uptake. Similar uptake pattern of 99mTc MDP and fluorine-18 fluorodeoxyglucose (18F FDG) in hepatic metastasis was not already notified. In our case, initial tumor necrosis and subsequent intracellular calcif...

In order to investigate the feasibility of the assessment of renal function with 99mTc-MDP, we compared renographical images, renogram patterns and the glomerular filtration rate (GFR) obtained by means of a modified Gates' method and 200 MBq of 99mTc-MDP with those obtained by means of 99mTc-DTPA. Because 19 of 20 patients had malignant tumors in the genitourinary tract, there was no differenc...

a 65 year-old overweight man with a history of prostate cancer was referred to our nuclear medicine department for bone scanning. anterior projection images showed two small foci of increased radiotracer uptake corresponding to the anterior arcs of the right and left sixth ribs, which were interpreted as suspicious for metastatic involvement. eight months later the patient was referred for foll...

To the Editor: Pleural malignant mesothelioma (MM) is an uncommon neoplasm with poor prognosis, strongly related to asbestos exposure, arising from mesothelial cells of the pleura. Pleurodynia is its most usual symptom, whereas the presence of pleural effusion combined with thickened pleura and calcified plaques in both computed tomographic (CT) images and respective histopathological findings ...

BACKGROUND Skeletal uptake of 99mTc labelled methylene diphosphonate (99mTc-MDP) is used for producing images of pathological bone uptake due to its incorporation to the sites of active bone turnover. This study was done to validate bone turnover markers using total skeletal uptake (TSU) of 99mTc-MDP. METHODS 22 postmenopausal women (52-80 years) volunteered to participate. Scintigraphy was p...

A 57 years old man was diagnosed by histology of left axillary node as having diffuse large B cell lymphoma. Laboratory investigations revealed hypercalcemia with serum calcium level of 2.9mol/L (normal range: 2.08-2.60). Other blood examinations including complete blood count, coagulation markers, serum parathyroid hormone (PTH), liver and renal function and electrolytes other than calcium wer...

Bone scintigraphy is a sensitive and popular method for imaging a wide array of benign or malignant skeletal abnormalities. However, the uptake of tracers used for bone scintigraphy may be observed in various extraosseous sites, thereby limiting its specificity. It is difficult to correctly localize such sites of uptake on planar bone scintigraphy alone. The addition of hybrid single-photon emi...