نتایج جستجو برای: Indol

تعداد نتایج: 1726  

2015
Prasanna K. Vuram C. Kabilan Anju Chadha

A simple and efficient method for the synthesis of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-di(indolyl)indolin-2-ones using microwave irradiation without catalyst and solvent is described. A series of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-di(indolyl)indolin-2ones have been synthesized in very short reaction times of 5 and 10 minutes and in yields ranging from 31% to 98%...

2017
M. J. Corr S. V. Sharma C. Pubill-Ulldemolins R. T. Bown P. Poirot D. R. M. Smith C. Cartmell A. Abou Fayad R. J. M. Goss

Experimental For the synthesis of: Sodium 2'-(Dicyclohexylphosphanyl)-2,6-diisopropyl-(1,1-biphenyl)-4-sulfonate (sXPhos) 12 4 Standard Reaction Procedure of 5-bromoindole 15 under reflux: 5 Microwave Reaction Procedure of 5-bromoindole 15: 5 Standard Microwave Reaction Procedure for Tryptophans: 5 (S)-2-Amino-3-(5-(phenylethynyl)-1H-indol-3-yl)propanoic acid 19 6 (S)-2-Amino-3-5-((3-fluorophen...

Journal: :The Journal of Experimental Medicine 1938
C. P. Rhoads W. Halsey Barker

Indol is mildly hemolytic when fed to dogs taking normal diets.

Journal: :The Journal of Experimental Medicine 2003
Theobald Smith

The Dunham-Bujwid indol test, used originally to distinguish cholera spirilla from other spirilla, was applied by Kitasato to bacteria other than those of Asiatic cholera, notably the colon bacillus and the typhoid bacillus, and today the test for indol is, by common consent, used regularly in the study of bacteria. As a result of its application we now know of two classes of indol-producing ba...

Journal: :Acta crystallographica. Section C, Crystal structure communications 2010
John Spencer Babur Z Chowdhry Samiyah Hamid Andrew P Mendham Louise Male Simon J Coles Michael B Hursthouse

The solid-state structures of a series of seven substituted 3-methylidene-1H-indol-2(3H)-one derivatives have been determined by single-crystal X-ray diffraction and are compared in detail. Six of the structures {(3Z)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2(3H)-one, C(13)H(10)N(2)O, (2a); (3Z)-3-(2-thienylmethylidene)-1H-indol-2(3H)-one, C(13)H(9)NOS, (2b); (3E)-3-(2-furylmethylidene)-1H-indol...

Journal: :The Journal of Experimental Medicine 1938
C. P. Rhoads D. K. Miller

1. Indol, orally administered, causes anemia when certain deficient diets are fed. 2. The same amount of indol causes no considerable hematologic disturbance when normal diets are fed. 3. The anemia can be cured by supplementing the diet with liver extract, or by substituting a normal diet for the deficient diet. 4. Neither the diet alone nor the administration of indol alone produces marked an...

Journal: :Acta pharmaceutica 2008
Nadeem Siddiqui M Shamsher Alam Waquar Ahsan

A series of new 5-(1H-indol-3-yl)methyl-4-(substituted aryl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones (4a-g), 5-(1H-indol-3-yl)methyl-N-(substituted aryl)-1,3,4-oxadiazol-2-amines (5a-g) and 5-(1H-indol-3-yl)methyl-N-(substituted aryl)-1,3,4-thiadiazol-2-amines (6a-g) were prepared by treating 2-(1H-indol-3-yl)acetyl-N-(substituted phenyl) hydrazine carbothioamides (3a-g) with suitable reagents....

Journal: :Colloids and surfaces. B, Biointerfaces 2014
Qiu-Yun Chen Zhi-Wei Wang Xia Yang Li Wang

Multifunctional silica nano-vehicles (SiO2@indol-IL) and magnetic nanoparticles (Fe3O4@indol-IL) were constructed through the Schiff bases condensation of indole-3-carboxaldehyde and 4-acetyl-N-allyl pyridinium chloride (ILs) with the amine groups of silica and magnetic nanoparticles. SiO2@indol-IL can inhibit the proliferation of HepG-2 cells in 48 h. Fe3O4@indol-IL can mimic the function of c...

2007
A. Sanz A. M. G. Carril M. P. Matía J. L. Novella J. Alvarez-Builla

An improved multistep synthesis of {3-(2-dimethylamino-ethy1)-2-[3-(2dimethylaminoethyl)-1H-indol-5-ylmethyl]-1H-indol-5-yl}-N-methyl-methanesulfonamide, the main Sumatriptan impurity, is described, as a model for other related triptan derivatives.

Journal: :Acta pharmaceutica 2008
Mohammad Amir Sadique Akhtar Javed Harish Kumar

Twelve new 4-(1H-indol-3-yl)-6-phenyl-1,2,3,4-tetrahydropyrimidin-2-ones/thiones (7-18) have been synthesized by reacting 1-aryl-3-(1H-indol-3-yl)-2-propen-1-one with urea and thiourea in ethanolic potassium hydroxide. Their structures have been confirmed by IR, 1H NMR and mass spectral data. The compounds were tested for their anti-inflammatory activity. Test results revealed that compounds sh...

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