a new group of 4-(imidazolylmethyl) quinoline derivatives possessing a methylsulfonyl cox-2 pharmacophore at the para position of the c-2 phenyl ring were designed and synthesized as selective cox-2 inhibitors and in-vitro anti breast cancer agents. in-vitro cox-1 and cox-2 inhibition studies showed that all the compounds were potent and selective inhibitors of the cox-2 isozyme with ic50 value...

objective the standard of hygiene in daily life and hospitals can be increased by the use of new antimicrobial fibers, which diminish the danger of pathogenic bacteria. in this study, the antimicrobial effect of special fibers on some staphylococcus isolates was investigated. materials and methods the antimicrobial effect of special type of fibers produced in isfahan poly acryl plant on three s...

purpose: in this study the inhibitory effect of eucalyptus extracts as a natural and herbal antibacterial substance was evaluated against pseudomonas aeruginosa strains (8821m and atcc27853). material and methods: the mic (minimal inhibitory concentration) of alcoholic and aquatic extracts of eucalyptus was determined using the tube and agar dilution methods. the growth rate of pseudomonas aer...

conclusions the kin gingival chlorhexidine mouthwash has a greater effect than behsa and boht mouthwashes on oral microorganisms and is recommended to be used for plaque chemical inhibition. results the mics for kin gingival, behsa and boht mouthwashes were 0.14, 0.48 and 1000 micrograms/ml using the tube method for s. mutans, respectively. the mbcs for the mentioned mouthwashes were 0.23, 1.9 ...

the ability of subminimum inhibitory concentrations (sub-mics) of antibiotics to affect the virulence factors of bacteria may be an important criterion in selecting an antibiotic for therapy. proteus mirabilis is one of the most frequently seen pathogens in urinary tract infections. the aim of this study was to analyze the effects of some antibiotics on two important virulence factors of p. mir...

conclusions our experimental and in silico findings may provide new insight in the complex molecular pathways of drug resistance and also could assist design an efficient therapeutic strategy for aspergillosis treatment. results four out of five isolates revealed cyp51a and mdr1 mrna overexpression. interestingly, the isolate, which was negative for cyp51a and mdr1 mrna expression showed a high...

a laboratory experiment was conducted to determine the allelopathic effect of residues aqueous extract of two ecotype of swallowwort (cynanchum acutum l.) on germination traits of wheat (triticum aestivum l.). a factorial experiment based on a completely randomized design with four replications was conducted at islamic azad university of karaj in 2012. factors were two swallowwort ecotype (ghaz...

aim and back ground: impulsivity and risky decision making is a core element of plenty of individual and social deficits. on the other hand, history of attention deficit disorder and hyperactivity has been reported in many people with these problem particularly addiction. decision making requires basic cognition function such as inhibition, working memory and attention. the aim of the current s...

background and purpose: candidiasis, an important fungal infection, is considered the fourth most common nosocomial blood stream infection. nowadays, because of increased fungal resistance to antibiotics, the use of herbal medicine has gained particular attention. cyclamen species are medicinal plants containing triterpenoid saponins, which are shown to have antimicrobial properties. materials ...

background: leukemia inhibitory factor (lif) is a neurortophic cytokine which plays an important role in the neural cell survival. expression of lif and its receptor, lifr, in different brain regions has been demonstrated. based on evidences lif plays an important role in the modulation of neurogenesis and glial responses to injury. up-regulation of lif after central nervous system (cns) damage...