Background: The ovariectomized animals are good models to evaluate the effect of different steroid hormone treatments on implantation events and the pattern of integrin expression. Therefore, this study was performed to compare the expression of integrins and osteopontin (OPN) in correlation with pinopode development in ovariectomized mice endometrium which was subjected to steroid hormones. Me...

background cyclosporine a (csa)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of csa itself or from reactive oxygen species (ros) overproduction. objectives in this study we aimed to identify the cellular mechanisms underlying csa-induced hepatic injury by investigating the activation patterns of the antioxidant enzymes,...

Introduction: Although the effect of adriamycin, a chemical drug used to treat cancer, is known to affect gametogenesis and ovarian function, the drug’s effect on endometrial receptivity and expression of integrin genes is unclear. To fill this gap, we aimed to investigate the effect of adriamycin on the expression of integrin genes that play a role in endometrial receptivity. Methods: A total...

Abstract The LIM domain-dependent localization of the adapter protein paxillin to β3 integrin-positive focal adhesions (FAs) is not mechanistically understood. Here, by combining molecular biology, photoactivation and FA-isolation experiments, we demonstrate specific contributions each domain reveal multiple interactions in adhesion-complexes. Mutation integrin at a putative binding site (β3 VE...

Introduction: The implantation is a complex procedure that involves many molecules. One of these molecules is integrin specially &alphav&beta3 which serves as receptor for components of extra cellular matrix to act as bridging molecules between the blastocyst and the endometrial surface during the implantation process. By blocking &alphav&beta3 interactions, the implantation can be impaired. ...

Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, mechanisms of integrin localization and regulation in filopodia are poorly defined. Here, we observed that active integrins accumulate at tip myosin-X(MYO10)-positive while inactive uniformly distributed. RNAi depletion 10 activity modulators identified talin as principal activator filopodia. Delet...

background: the ovariectomized animals are good models to evaluate the effect of different steroid hormone treatments on implantation events and the pattern of integrin expression. therefore, this study was performed to compare the expression of integrins and osteopontin (opn) in correlation with pinopode development in ovariectomized mice endometrium which was subjected to steroid hormones. me...

objective: considering the importance of integrin molecules in the implantation and lack of sufficient information in the expression pattern of these molecules in various phases of estrous cycle. it seemed to be necessary to investigate these molecules in mouse endometrial during the various phases of oestrous cycle. materials and methods: female nmri mice (n=15) aged 6-8 weeks were studied. v...

Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, capable inhibiting cell adhesion to extracellular matrix (ECM). This functional site usually buried within molecular structure FN, but can be exposed by conformational changes and proteolytic cleavage. Peptide FNIII14 induce a change in β1-integrin active inactive form, c...