BACKGROUND The use of adjunct, non-opioid agents is integral for pain control following total hip and knee arthroplasty. Literature comparing safety profiles of intravenous acetaminophen versus opioids is lacking. OBJECTIVE To determine whether there is a difference in frequency and type of adverse effects between intravenous acetaminophen-treated and non-intravenous acetaminophen-treated pat...

conclusions intravenous acetaminophen reduced pain following outpatient urological surgery more significantly than meperidine. patients and methods in a prospective, randomized, double-blind clinical trial, 100 outpatients of urological surgery were studied in two groups of acetaminophen (a) and meperidine (m). patients in group a received 1g of acetaminophen in 100 ml saline within 15 minutes ...

conclusions administration of intravenous acetaminophen before ending appendectomy might be more effective than meperidine in postoperative pain management while having fewer complications. patients and methods in this randomized clinical trial study, forty patients with asa- class i or ii who were candidates for emergency appendectomy were randomly divided into two groups. induction and mainte...

conclusions post-operative pain in rectal acetaminophen group was less than that in intravenous acetaminophen group, and rectal acetaminophen group demanded their first additional analgesic medication later. results data analysis indicated a significant relationship between reduction of postoperative pain and the use of intravenous or rectal acetaminophen (p = 0.0001); in group receiving iv ace...

BACKGROUND Intravenous acetaminophen injection (paracetamol) is marketed in Europe for the management of acute pain. A repeated-dose, randomized, double-blind, placebo-controlled, three-parallel group study was performed to evaluate the analgesic efficacy and safety of intravenous acetaminophen as compared with its prodrug (propacetamol) and placebo. Propacetamol has been available in many Euro...

background: opioid analgesics are the mainstay of the treatment of postoperative pain. appropriate monitoring of patients receiving opioid analgesics is essential to detect those with side effects such as respiratory depression. the discovery of acetaminophen as a cox-3 variant may represent a primary central mechanism by which acetaminophen decrease pain. the aim of this study was to assess th...

Background: Previous studies have considered patent ductus arteriosus (PDA) a common finding in premature infants, leading to complications such as intracranial hemorrhage, necrotizing enterocolitis and pulmonary dysplasia. The aim of this study was to assess and compare the efficacy of oral ibuprofen and intravenous acetaminophen in the closure of arterial duct in premature newborns. We also e...

BACKGROUND Pain relief after surgery is an essential component of postoperative care. OBJECTIVES The purpose of this study was to compare the efficacy of intravenous acetaminophen and intravenous meperidine in pain relief after outpatient urological surgery. PATIENTS AND METHODS In a prospective, randomized, double-blind clinical trial, 100 outpatients of urological surgery were studied in ...

background a few studies are available actually comparing the clinical efficacy of intravenous acetaminophen with other medications such as dexamethasone to inhibit postoperative adverse events in children. objectives this randomized blinded controlled trial was designed to compare controlling status of postoperative events in children after tonsillectomy randomized to receive either intravenou...

BACKGROUND Postoperative pain control (especially, after adenotonsillectomy) has a very important effect on recovery time, hospitalization duration, hemodynamic disorders, bleeding, nausea, vomiting and medical costs. OBJECTIVES The aim of this study was to investigate and compare the effects of intravenous and rectal acetaminophen on controlling post-adenotonsillectomy pain in children, and ...