We develop and test a new pipeline in CASP10 to predict protein structures based on an interplay of I-TASSER and QUARK for both free-modeling (FM) and template-based modeling (TBM) targets. The most noteworthy observation is that sorting through the threading template pool using the QUARK-based ab initio models as probes allows the detection of distant-homology templates which might be ignored ...

I-TASSER is an automated pipeline for protein tertiary structure prediction using multiple threading alignments and iterative structure assembly simulations. In CASP9 experiments, two new algorithms, QUARK and fragment-guided molecular dynamics (FG-MD), were added to the I-TASSER pipeline for improving the structural modeling accuracy. QUARK is a de novo structure prediction algorithm used for ...

I-TASSER is a hierarchical protocol for automated protein structure prediction and structure-based function annotation. Starting from the amino acid sequence of target proteins, I-TASSER first generates full-length atomic structural models from multiple threading alignments and iterative structural assembly simulations followed by atomic-level structure refinement. The biological functions of t...

The recently developed TASSER (Threading/ASSembly/Refinement) method is applied to predict the tertiary structures of all CASP6 targets. TASSER is a hierarchical approach that consists of template identification by the threading program PROSPECTOR_3, followed by tertiary structure assembly via rearranging continuous template fragments. Assembly occurs using parallel hyperbolic Monte Carlo sampl...

‎in this article‎, ‎we introduce a new type iterative scheme for‎ ‎approximating common fixed points of two asymptotically‎ ‎nonexpansive mappings is defined‎, ‎and weak and strong convergence‎ ‎theorem are proved for the new iterative scheme in a uniformly‎ ‎convex banach space‎. ‎the results obtained in this article‎ ‎represent an extension as well as refinement of previous known‎ ‎resu...

Background: The present study has been designed with the aim of evaluating A-kinase anchoring proteins 3 (AKAP3)and Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) gene mutations and prediction of 3D proteinstructure for ligand binding activity in the cases of non-obstructive azoospermic male.Materials and Methods: Clinically diagnosed cases of non-obstructive azoos...

An improved TASSER (Threading/ASSEmbly/Refinement) methodology is applied to predict the tertiary structure for all CASP7 targets. TASSER employs template identification by threading, followed by tertiary structure assembly by rearranging continuous template fragments, where conformational space is searched via Parallel Hyperbolic Monte Carlo sampling with an optimized force-field that includes...

Abstract Background Tumour necrosis factor ligand superfamily member 8 (TNFL8) is a cytokine that plays vital roles in immune activations and inflammatory responses through its interaction with the tumour member. Despite multiple studies on involvement of receptor response, there limited information molecular characterization structural elucidation cytokine. Considering significance cytokine, t...

‎In this article‎, ‎we introduce a new type iterative scheme for‎ ‎approximating common fixed points of two asymptotically‎ ‎nonexpansive mappings is defined‎, ‎and weak and strong convergence‎ ‎theorem are proved for the new iterative scheme in a uniformly‎ ‎convex Banach space‎. ‎The results obtained in this article‎ ‎represent an extension as well as refinement of previous known‎ ‎resu...