نتایج جستجو برای: K/Na

تعداد نتایج: 87  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Thomas J Tamsett Kelly E Picchione Arin Bhattacharjee

Although sodium-activated potassium channels (KNa) have been suggested to shape various firing patterns in neurons, including action potential repolarization, their requirement for high concentrations of Na+ to gate conflicts with this view. We characterized KNa channels in adult rat dorsal root ganglion (DRG) neurons. Using immunohistochemistry, we found ubiquitous expression of the Slack KNa ...

Journal: :The Journal of General Physiology 1990
C Haimann L Bernheim D Bertrand C R Bader

Whole-cell voltage clamp and single-channel recordings were performed on cultured trigeminal ganglion neurons from quail embryos in order to study a sodium-activated potassium current (KNa). When KNa was activated by a step depolarization in voltage clamp, there was a proportionality between KNa and INa at all voltages between the threshold of INa and ENa. Single-channel recordings indicated th...

2015
Pedro L Martinez-Espinosa Jianping Wu Chengtao Yang Vivian Gonzalez-Perez Huifang Zhou Hongwu Liang Xiao-Ming Xia Christopher J Lingle Richard Aldrich

Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na(+)-dependent K(+) (KNa) channels. Progress in understanding KNa channels has been hampered by the absence of specific tools and methods for rigorous KNa identification in native cells. Here, we report the genetic disruption of both Kcnt1 and Kcnt2, confirm the loss of Slo2.2 and Slo2.1 protein, respectively, in KO animals,...

2015
Yue Ban Benjamin E. Smith Michael R. Markham

30 The bioelectrical properties and resulting metabolic demands of electrogenic cells are 31 determined by their morphology and the subcellular localization of ion channels. The electric 32 organ cells (electrocytes) of the electric fish Eigenmannia virescens generate action potentials 33 (APs) with Na currents >10 microamperes and repolarize the AP with Na-activated K (KNa) 34 channels. To bet...

Journal: :Journal of neurophysiology 2015
Izumi Takahashi Masami Yoshino

In this study, we examined the functional coupling between Na(+)-activated potassium (KNa) channels and Na(+) influx through voltage-dependent Na(+) channels in Kenyon cells isolated from the mushroom body of the cricket Gryllus bimaculatus. Single-channel activity of KNa channels was recorded with the cell-attached patch configuration. The open probability (Po) of KNa channels increased with i...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1992
T M Egan D Dagan J Kupper I B Levitan

We have used single-channel recording techniques to investigate the properties of sodium-activated potassium channels (KNa channels) in cultured rat olfactory bulb neurons, and in large neurons in the mitral cell layer of thin slices of olfactory bulb. Ion channels highly selective for potassium over sodium and chloride, and requiring 10-180 mM internal sodium (Nai) for their activation, were p...

2015
Izumi Takahashi Masami Yoshino

13 14 In this study, we examined the functional coupling between Na+-activated 15 potassium (KNa) channels and Na+-influx through voltage-dependent Na+ 16 channels in Kenyon cells isolated from the mushroom body of the cricket 17 Gryllus bimaculatus. Single channel activity of KNa channels was recorded 18 with the cell-attached patch configuration. The open probability (Po) of KNa 19 channels i...

Journal: :Journal of neurophysiology 2008
Kozue Aoki Kumiko Kosakai Masami Yoshino

Recent studies have suggested that octopamine (OA) and dopamine (DA) play important roles in mediating the reward and punishment signals, respectively, in olfactory learning in insect. However, their target molecules and the signaling mechanisms are not fully understood. In this study, we showed for the first time that OA and DA modulate the Na+-activated K+ (KNa) channels in an opposite way in...

Journal: :Transfusion 2004
J M Moulds B J Thomas O Doumbo D A Diallo K E Lyke C V Plowe J A Rowe D J Birmingham

BACKGROUND DNA mutations resulting in the McCoy and Swain-Langley polymorphisms have been identified on complement receptor 1 (CR1)-a ligand for rosetting of Plasmodium falciparum-infected RBCs. The molecular identification of the Kna/Knb polymorphism was sought to develop a genotyping method for use in the study of the Knops blood group and malaria. STUDY DESIGN AND METHODS CR1 deletion cons...

Journal: :Journal of neurophysiology 2015
Yue Ban Benjamin E Smith Michael R Markham

The bioelectrical properties and resulting metabolic demands of electrogenic cells are determined by their morphology and the subcellular localization of ion channels. The electric organ cells (electrocytes) of the electric fish Eigenmannia virescens generate action potentials (APs) with Na(+) currents >10 μA and repolarize the AP with Na(+)-activated K(+) (KNa) channels. To better understand t...

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