The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear. We found that deacetylation of ATR-interacting protein (ATRIP), a regulatory partner of ATR, by SIRT2 potentiates the ATR checkpoint. SIRT2 interacts with and deacetylates ATRIP at lysine 32 (...

The finite model property of the quasi-transitive modal logic K32 = K ⊕ ✷✷p → ✷✷✷p is proved. This modal logic is conservatively extended to the tense logic Kt32. We present a Gentzen sequent calculus Gt32 for Kt 3 2 which admits cut elimination. The sequent calculus Gt 3 2 is shown to have the finite model property by a construction of finite syntactic model. It follows that Kt32 has the finit...

A firm engaged in activities which are environmentally risky has private information both on its choice of safety care and on the level of its assets. JEL Classification: K13, K32, L51.

The paper describes the technology of nickel-alumina composite coatings obtained by low-pressure cold spray (LPCS). content alumina reinforcement was optimized mixing commercial K32, being a mechanical mixture Al2O3 + 50 wt% Ni, with Ni-cladded powders developed in present study. cladded were prepared hydrogen reduction method. Two including Ni-films covering particles developed: 70 Ni (powder ...

PURPOSE To investigate the interpolymer complexation between Carbopol 934P (CP) and various grades of polyvinylpyrrolidone (PVP) (K90, K32, C15, and VA/S-630). METHODS Amount of fresh and dried CP-PVP complexes, water retaining capacity, apparent density, pH, conductivity, FTIR, swelling and adhesion strength were studied. RESULTS Interpolymer complexation occurred between CP and all the PV...

Fly ash merupakan limbah pembakaran batubara yang bisa dimanfaatkan untuk bahan paving block. Penelitian ini bertujuan menemukan komposisi terbaik dari block, pengujian kuat tekan, dan serapan air. Metode digunakan adalah eksperimen skala laboratorium. Eksperimen menggunakan variabel formula bahan. Formula 1 terdiri semen : pasir fly dengan K11 (1 5 0;); K12 0,5); K13 1). 2 putih K21 K22 K23 3 ...

In a market where firms with different characteristics decide upon both the level of emissions and their reports, we study the optimal audit policy for an enforcement agency whose objective is to minimize the level of emissions. We show that it is optimal to devote the resources primarily to the easiest-to-monitor firms and to those firms that value pollution the less. Moreover, unless the budg...

Economic theory predicts that abortion laws affect sexual behavior since they change the marginal cost of having risky sex. We estimate the impact of abortion laws on sexual behavior by reported gonorrhea incidence. Our data panel includes 41 countries for which consistent gonorrhea data are available for 1980–2000. Compared with laws permitting abortion only to save the pregnant woman’s life o...

Compliance is an important issue in environmental regulation. We discuss some of the key elements of the problem and analyze a situation where emissions are not random and firms are risk-neutral. We study the firm’s decision on emissions and compliance when the environmental regulation is based on standards and the enforcement agency audits the firm with a certain probability. We compare total ...

Notwithstanding great progress in scientific and economic understanding of climate change, it has proven difficult to forge international agreements because of free-riding, as seen in the defunct Kyoto Protocol. This study examines the club as a model for international climate policy. Based on economic theory and empirical modeling, it finds that without sanctions against non-participants there...