نتایج جستجو برای: KIR Genes
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Introduction: Killer-cell Immunoglobulin-like Receptors (KIR) are the members of inhibitory and activating receptors expressed chiefly by the natural killer cells (NK). KIR proteins operate as receptors detecting human leukocyte antigen class Ι molecules (HLA). KIRs and their class Ι HLA ligands contribute in the pathogenesis of many kinds of diseases. The aim of this study was to genotypic ana...
Background: Natural Killer (NK) cells, through mechanisms such as cytotoxicity and cytokine production, are among the first line of defence against infections. The ability of NK cytotoxicity is related to Killer cell immunoglobulin-like receptors (KIR) found on the cell surface. Interaction between KIRs and human leukocyte antigen (HLA) class I molecules regulate NK cells responses to eliminate...
Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. Objective: To investigate the KIR gene profiles in relation to susceptibility to Graves’ disease in patients with ophthalmopathy. Methods: KIR genes profiles were ana...
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors which control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. H...
Background: Natural killer (NK) cells are the effector cells of innate immunity that respond to infection and tumor. Interactions between killer cell immunoglobulin like receptors (KIR) and human leukocyte antigen (HLA) class I molecules regulate NK cells responses to eliminate infected and transformed cells. Objective: To investigate the impact of KIR genes, HLA ligand genes, and KIR-HLA combi...
background: killer cell immunoglobulin-like receptors (kir) are expressed on nk cells and a subset of t cells. the variable kir receptors along with their ligands, hla class i, influence risk for autoimmune and malignant diseases. objective: to investigate the kir gene profiles in relation to susceptibility to graves’ disease in patients with ophthalmopathy. methods: kir genes profiles were ana...
background: natural killer (nk) cells are the effector cells of innate immunity that respond to infection and tumor. interactions between killer cell immunoglobulin like receptors (kir) and human leukocyte antigen (hla) class i molecules regulate nk cells responses to eliminate infected and transformed cells. objective: to investigate the impact of kir genes, hla ligand genes, and kir-hla combi...
Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML;...
background: interaction between killer cell immunoglobulin-like receptors (kir) and human leukocyte antigen (hla) class i molecules is important for regulation of natural killer (nk) cell function. objective: the aim of this study was to investigate the impact of compound kir-hla genotype on susceptibility to acute leukemia. methods: cohorts of iranian patients with acute myeloid leukemia (aml;...
Purpose: The immune responses of natural killer (NK) cells against cancer vary by patient. Killer Ig-like receptors (KIRs), which are some the major involved in regulating NK cell activity for killing cells, have significant genetic variation. Numerous studies suggested a potential association between variation KIR genes and risk development or prognosis various types. However, an variations gl...
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