نتایج جستجو برای: Keywords: Harmine

تعداد نتایج: 1978292  

Journal: :journal of physical and theoretical chemistry 0
neda ahmadinejad young research arezoo tahan 2semnan branch, islamic azad university, semnan, iran mostafa talebi tari1 young researchers and elite club, yadegar-e-imam khomeini(rah) , shahr-e-rey- branch, islamic azad university, tehran, iran

abstractl density functional theory (dft) was used to investigate the effects of intra-moecular interactions and implicit water molecules on the relative stability and the nmr shielding tensors of hallucinogenic harmine in the monomeric and dimeric states. results represented that the relative stability and the nmr shielding tensors are dependent on the resonance interactions and chemical envir...

2012
Gislaine Z. Réus Roberto B. Stringari Cinara L. Gonçalves Giselli Scaini Milena Carvalho-Silva Gabriela C. Jeremias Isabela C. Jeremias Gabriela K. Ferreira Emílio L. Streck Jaime E. Hallak Antônio W. Zuardi José A. Crippa João Quevedo

The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmin...

2017
Shuping Li Yunpeng Zhang Gang Deng Yuwen Wang Shenglan Qi Xuemei Cheng Yueming Ma Yan Xie Changhong Wang

Harmaline and harmine occur naturally in plants and are distributed endogenously in human and animal tissues. The two β-carboline alkaloids possess potential for treating Alzheimer's disease, Parkinson's disease, depression and other central nervous system diseases. However, studies have showed that the two compounds have similar structures but with quite different bioavailability. The aim of t...

2011
Thayele Purayil Hamsa Girija Kuttan

BACKGROUND Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells. METHODS B16F-10 melanoma cells were treated in the presence and absence of harmine in vitro. Morphological changes, cell cycle and expression of variou...

2015
Siwen Li Aqin Wang Fan Gu Zhaohui Wang Caiping Tian Zhiyu Qian Liping Tang Yueqing Gu

Harmine is a beta-carboline alkaloid found in medicinal plant PeganumHarmala, which has served as a folk anticancer medicine. However, clinical applications of harmine were limited by its low pharmacological effects and noticeable neurotoxicity. In this study, we modified harmine to increase the therapeutic efficacy and to decrease the systemic toxicity. Specifically, two tumor targeting harmin...

2016
Tao Nie Xiaoyan Hui Liufeng Mao Baoming Nie Kuai Li Wei Sun Xuefei Gao Xiaofeng Tang Yong Xu Baishan Jiang Zhengcao Tu Peng Li Ke Ding Weiping Han Shaoping Zhang Aimin Xu Sheng Ding Pentao Liu Adam Patterson Garth Cooper Donghai Wu

Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice. However its effect on adipose tissue browning is unknown. Here we reveal that harmine antagonizes high fat diet-induced adiposity. Harmine-treated mice gained less weight on a high fat diet and displayed increased energy expenditure and adipose tissue thermogenesis. In vitro, harmine potently induced the...

Abstractl Density functional theory (DFT) was used to investigate the effects of intra-moecular interactions and implicit water molecules on the relative stability and the NMR shielding tensors of hallucinogenic harmine in the monomeric and dimeric states. Results represented that the relative stability and the NMR shielding tensors are dependent on the resonance interactions and chemical envir...

2017
Shu Ruan Feng Jia Jianbo Li

Thyroid cancer is one of the most common types of cancer in endocrine system. In latest studies, harmine has been proved to inhibit the growth of several cancers in vitro and in vivo. In the current study, we evaluated the in vitro and in vivo anticancer efficiency of harmine against thyroid cancer cell line TPC-1. The in vitro cytotoxicity of harmine evaluated by XTT assay indicated that harmi...

Journal: :Neurotoxicology 2010
Elan D Louis Wendy Jiang Marina Gerbin Mary M Mullaney Wei Zheng

INTRODUCTION Harmane, a potent tremor-producing β-carboline alkaloid, may play a role in the etiology of essential tremor (ET). Blood harmane concentrations are elevated in ET cases compared with controls yet the basis for this elevation remains unknown. Decreased metabolic conversion (harmane to harmine) is one possible explanation. Using a sample of >500 individuals, we hypothesized that defe...

Journal: :Hepatobiliary & pancreatic diseases international : HBPD INT 2011
Ming-Rong Cao Qiang Li Zhi-Long Liu Hui-Hui Liu Wei Wang Xiao-Li Liao Yun-Long Pan Jian-Wei Jiang

BACKGROUND Harmine has antitumor and antinociceptive effects, and inhibits human DNA topoisomerase. However, no detailed data are available on the mechanisms of action of harmine in hepatocellular carcinoma. This study aimed to investigate the effects of harmine on proliferation and apoptosis, and the underlying mechanisms in the human hepatocellular carcinoma cell line HepG2. METHODS The pro...

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