In the first report on the chemical structure of a nonmammalian LH-RH, chicken hypothalamic LH-RH was demonstrated to be [Gln8]LH-RH [2-4]. However, these studies and subsequent reports [7,8] did not totally exclude the possibility of a reverse sequence of the two amino acids Leu-Gln. In view of the recently described structure of salmon brain LH-RH as [Trp7,Leu8]LH-RH [9], we undertook to conf...

The effects of prolactin (PRL), growth hormone (GH) and luteinizing hormone (LH) on testicular LH receptor concentration and on testosterone synthesis in response to LH (testicular responsiveness) was studied in mature intact and hypophysectomized rats. Hypophysectomy reduced LH receptor concentration by 80 o/o and testicular responsiveness to LH by 70a/o , 7 days after surgery. Daily treatment...

We tested the hypothesis that insulin-like growth factor-I (IGF-I) stimulates ovarian androgen production by increasing theca-interstitial cell luteinizing hormone (LH) binding affinity and/or binding capacity. We then investigated the role of transcriptional and translational events in mediating these actions of IGF-I. LH bound to saturable, high affinity binding sites on rat ovarian theca-int...

The generalized conductance ϕ(G,H) between two weighted graphs G and H on the same vertex set V is defined as ratioϕ(G,H)=minS⊆V⁡capG(S,S¯)capH(S,S¯), where capG(S,S¯) total weight of edges crossing from S⊆V to S¯=V−S. We show that minimum eigenvalue λ(LG,LH) pair Laplacians LG LH satisfiesϕ(G,H)≥λ(LG,LH)≥ϕ(G,H)ϕ(G)/16, ϕ(G) standard G. A cut meets this bound can be obtained eigenvector corresp...

The role of luteinizing hormone (LH) and LH-releasing hormone (LH-RH) in the maintenance of early pregnancy in rats was studied. Serum levels of progesterone (P) and LH were measured daily in untreated pregnant rats from Day 4 through parturition. Serum levels of P and LH were determined on Days 11 and 15 of pregnancy in animals treated with antisera to LH (LH-A/S) and to LH-RH (LH-RH-A/S) on...

We investigated the effects of estradiol on bioactive luteinizing hormone (LH) release in normal men using two complementary strategies: (i) steady state intravenous infusions of estradiol at its endogenous production rate, and (ii) oral administration of the antiestrogen, tamoxifen HCl. Immunoreactive and biologically active LH were monitored by radioimmunoassay and the rat interstitial cell t...

In previous work we have shown that GABAB receptors are required for expression of absence seizures in the lethargic (lh/lh) mouse model; that lh/lh mice have increased numbers of GABAB binding sites compared to nonepileptic littermates (designated +/+); and that the magnitude of the increased number of GABAB receptors in lh/lh mice correlated positively with the frequency of absence seizures. ...

The preovulatory luteinizing hormone (LH) surge results from the integration of complex interactions among gonadal steroids and hypothalamic and pituitary hormones. To evaluate changes in LH secretory dynamics that occur during the rat LH surge, we have 1) obtained frequently sampled serum LH concentration time series, 2) used both waveform-dependent and waveform-independent convolution analyse...