Sterol regulatory-element binding proteins (SREBPs), sirtuin (SIRT1), and liver X receptor ? (LXR?) play important roles in regulating cholesterol metabolism mammals. However, little is known about the relationship between SIRT1, LXR?, SREBP-1 fish. In addition, knowledge of effects salinity on hepatic euryhaline teleosts fragmented. This study revealed that content was significantly different ...

Low testosterone in men is associated with increased cardiovascular events and mortality. Testosterone has beneficial effects on several risk factors including cholesterol, endothelial dysfunction inflammation as key mediators of atherosclerosis. Although evidence suggests anti-atherogenic, its mechanism action unknown. The present study investigates whether exerts anti-atherogenic by stimulati...

OBJECTIVE We previously reported that a systemic liver X receptor (LXR) agonist promoted macrophage reverse-cholesterol transport (mRCT) in vivo. Because LXR are expressed in multiple tissues involved in RCT (macrophages, liver, intestine), we analyzed the effect of tissue-specific LXR agonism on mRCT. METHODS AND RESULTS In initial studies, the systemic LXR agonist GW3965 failed to promote m...

Dopaminergic (DA) neurons derived from bone marrow derived mesenchymal stem cells (BMSCs) maybe a valuable source for cell replacement therapy in Parkinson disease. Recent studies showed that new functions of LXR and their ligands have been proposed to prevent PD in the adult nervous system. The present study was designed to observe the effect of liver X receptors (LXR) agonist on differentiati...

This article is available online at http://www.jlr.org early event in the development of atherosclerosis is the recruitment of macrophages to the subendothelial space of vessel walls and the uncontrolled uptake of oxidized or aggregated low density lipoprotein particles. Continued accumulation of oxidized or aggregated LDL by macrophages and an associated infl ammatory response leads to foam ce...

BACKGROUND Liver X receptor (LXR) α and LXR β (NR1H3 and NR1H2) are oxysterol-activated nuclear receptors involved in the control of major metabolic pathways such as cholesterol homeostasis, lipogenesis, inflammation and innate immunity. Synthetic LXR agonists are currently under development and could find applications in various fields such as cardiovascular diseases, cancer, diabetes and neur...

Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking, including absorption, excretion, catabolism, and cellular efflux, and possess both anti-inflammatory and antidiabetic actions. Accordingly, LXR is considered an appealing drug target for multiple indications. Synthetic LXR agonists demonstrated inhibition of atherosclerosis ...

Fatty acid metabolism is transcriptionally regulated by two reciprocal systems: peroxisome proliferator-activated receptor (PPAR) controls fatty acid degradation, whereas sterol regulatory element-binding protein-1c activated by liver X receptor (LXR) regulates fatty acid synthesis. To explore potential interactions between LXR and PPAR, the effect of LXR activation on PPAR signaling was invest...

Inflammation in response to excess low-density lipoproteins in the blood is an important driver of atherosclerosis development. Due to its ability to enhance ATP-binding cassette A1-dependent (ABCA1-dependent) reverse cholesterol transport (RCT), liver X receptor (LXR) is an attractive target for the treatment of atherosclerosis. However, LXR also upregulates the expression of sterol regulatory...

There is now convincing evidence that liver X receptor (LXR) is an important modulator of the inflammatory response; however, its mechanism of action remains unclear. This study aimed to examine the effect of LXR on the IL-12 family of cytokines and examined the mechanism by which LXR exerted this effect. We first demonstrated that activation of murine-derived dendritic cells (DC) with a specif...