the aim of this study is to determine whether there is a role of podoplanin and glutathione s-transferases t1 (gst-t1) expression in laryngeal squamous cell carcinoma. the study was completed with 33 patients and gene expression analysis was performed by qrt–pcr. the podoplanin and gst-t1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryn...

Background & Objective: Laryngeal squamous cell carcinoma (LSCC) is considered to be one of the most common cancers of the head and neck, accounting for roughly 90% of all malignant tumors of the larynx. To have a timely diagnosis for a better and practical therapy, molecular markers have to be investigated. The aim of this study was to determine the expression of Cyclin D1 (CD...

introduction: sentinel node mapping has been used for laryngeal carcinoma in several studies, with excellent results thus far.in the current study, we report our preliminary results on sentinel node mapping in laryngeal carcinoma using intra-operative peri-tumoral injection of a radiotracer.   materials and methods: patients with biopsy-proven squamous cell carcinoma of the larynx were included...

the association of squamous cell carcinoma of the larynx with thyroid papillary carcinoma is an unusual finding. from 2004 to 2011, approximately 250 patients underwent laryngectomies due to squamous cell carcinoma of the larynx at the otolaryngology department of khalili hospital, affiliated with shiraz university of medical sciences, shiraz, iran. in three patients, synchronous occurrence of ...

Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. Methods: Seventeen newly diagnosed, untre...

background: although the imbalance of cytokines in head and neck squamous cell carcinoma (hnscc) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. objective: to determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. methods: seventeen newly diagnosed, untre...

background: because of its effect on speech and swallowing, laryngeal squamous cell carcinoma is a devastating disease which has been shown to have a poor survival rate. abundant research is being carried out in search of novel biomarkers that can aid the process of diagnosis and treatment of this disease. fxyd3, a modulator of na/k-atpase, is presented as a biomarker in some cancers. fxyd3 exp...

introduction: a rare case of basaloid squamous cell carcinoma (bscc) of the larynx, which has not been previously reported, is described. case report: a 60-year-old man was presented to the otolaryngology department with progressive dyspnoea and dysphagia to solids for over a period of 1 week. direct laryngoscopy revealed a tumour at the laryngeal aspect of the epiglottis, which prolapsed into ...

BACKGROUND The diagnostic role of cyclooxygenase-2 (COX-2) expression in laryngeal atypical hyperplasia, vocal fold nodule, and laryngeal squamous cell carcinoma was examined. METHODS Specimens obtained from patients diagnosed with vocal fold nodule (n = 35), atypical hyperplasia (n = 35), laryngeal squamous cell carcinoma (n = 35), and clinical parameters were evaluated retrospectively. RE...

OBJECTIVE The present study was to investigate the effect of 1,25(OH)2D3 on the proliferation and apoptosis of Lscc-02 laryngeal squamous cell carcinoma cell line. METHOD Lscc-02 human laryngeal squamous cell carcinoma cell line was treated with 1,25(OH)2D3. Cell proliferation was evaluated by MTT assay, distribution of cell cycle and rate of apoptosis determined by flow cytometry, and cell m...