Kinesin is a dimeric motor with twin catalytic heads joined to a common stalk. Kinesin molecules move processively along microtubules in a hand-over-hand walk, with the two heads advancing alternately. Recombinant kinesin constructs with short stalks have been found to "limp", i.e., exhibit alternation in the dwell times of successive steps. Limping behavior implies that the molecular rearrange...

With the advent of cloud computing, thousands of machines are connected and managed collectively. This era is confronted with a new challenge: performance variability, primarily caused by large-scale management issues such as hardware failures, software bugs, and configuration mistakes. In our previous work [2] we highlighted one overlooked cause: limping hardware – hardware whose performance d...

Limp is an abnormal gait which can be caused by pain, muscular dysfunction or deformity. Limp is never normal and the cause should be established. There is a long list of possible diagnoses. A complete history and thorough physical examination are the most helpful tools in sorting out the various causes of limping. Laboratory tests and imaging studies should be based on findings in the history ...

BACKGROUND Leg length inequality (LLI) was identified as a problem of total hip arthroplasty soon after its introduction. Leg lengthening is the most common form of LLI. Possible consequences are limping, neuronal dysfunction and aseptic component loosening. LLI can result in an increased strain both on the contralateral hip joint and on the abductor muscles. We assessed the influence of leg le...

With the advent of cloud computing, thousands of machines are connected and managed collectively. This era is confronted with a new challenge: performance variability, primarily caused by large-scale management issues such as hardware failures, software bugs, and configuration mistakes. In this paper, we highlight one overlooked cause: limping hardware – hardware whose performance degrades sign...

Background: Limping in preschool-age children is a common chief complaint the orthopaedic clinic. Given breadth of limping etiologies, there variability evaluation these patients. The objectives our study are: 1) to describe epidemiology presenting with limp and 2) determine predictors identifying at risk for non-benign etiologies. Methods: This retrospective <6 years old tertiary care pedia...