Rheumatoid arthritis (RA) is a complex disease that involves both environmental and genetic factors. Elucidation of the basic etiologic factors involved in RA is essential for preventing and treating this disease. However, the etiology of RA, like that of other complex diseases, is largely unknown. In the present study, we conducted autosomal multipoint linkage scans using affected sib pairs by...

PURPOSE To provide an overview of essential elements of good governance of data linkage for health-related research, to consider lessons learned so far and to examine key factors currently impeding the delivery of good governance in this area. Given the considerable hurdles which must be overcome and the changing landscape of health research and data linkage, a principled, proportionate, risk-b...

BACKGROUND Little is known about the genes influencing dietary energy and nutrient intakes, despite evidence that these intakes are influenced by genetic factors. OBJECTIVE We aimed to identify, by using a genome-wide linkage analysis, chromosomal regions harboring genes that affect energy and macronutrient intakes. DESIGN Energy, carbohydrate, lipid, and protein intakes were assessed in 83...

the incidence of pre-lingual hearing loss (hl) is about 1 in 1000 neonates. more than 60% of cases are inherited. non-syndromic hl (nshl) is extremely heterogeneous: more than 130 loci have been identified so far. the most common form of nshl is the autosomal recessive form (arnshl). in this study, a cohort of 36 big arnshl pedigrees with 4 or more patients from 7 provinces of iran was investig...

Abstract The research aims to investigate the roles of market linkage for growth MSE in Ambo town. data were collected through questionnaires and interviews. A stratified sampling technique is used select among seven business sectors. Data analyzed using descriptive inferential statistics. study elicited five major factors that affects which include financial capacity, government support, entre...

Description R package for design of experiments for association studies for detection of linkage disequilibrium. Uses an existing deterministic power calculation for detection of linkage disequilibrium between a bi-allelic QTL and a bi-allelic marker, together with the Spiegelhalter and Smith Bayes factor to generate designs with power to detect effects with a given Bayes factor.

INTRODUCTION Efforts to increase awareness of HIV status have led to growing interest in community-based models of HIV testing. Maximizing the benefits of such programmes requires timely linkage to care and treatment. Thus, an understanding of linkage and its potential barriers is imperative for scale-up. METHODS This study was conducted in rural South Africa. HIV-positive clients (n=492) ide...

in two days; This number of eggs therefore has not received the exposure necessary to produce the change in crossing over. The culmination of the two days exposure is to be expected in those eggs so situated that 125 to 175 eggs will be laid before them. Such an interpretation makes it extremely likely that the change in the amount of crossing over is finally affected in the earliest oocytes, t...

For the calculation of linkage intensities, i t is of distinct advantage to back-cross the heterozygote on the double recessive since the gametic ratio can then be determined directly from the zygotic types. In some plants, as corn, for example, back-crosses are easily and readily made, but in others, as soy-beans, the practical difficulties attending artificial hybridization are too great to a...

The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the systematic genetic dissection of discrete Mendelian factors underlying quantitative traits in experimental organisms. We describe here a set of analytical methods that modify and extend the classical theory for mapping such...