Lipid peroxidation is a highly destructive process, which induces a plethora of alterations in structure and function of cellular membranes. It is involved in number of diseases and poisoning by several toxins. Lipid peroxidation occurs in response to oxidative stress, and a great diversity of aldehydes are formed when lipid hydroperoxides break down in biological systems. Among the aldehydic e...

BACKGROUND AND PURPOSE Heme-proteins, besides causing renal tubular obstruction, may contribute to rhabdomyolysis-induced renal injury through a heme-iron-mediated lipid peroxidation process. In the present study, we compared the combined therapy of a lipid peroxidation inhibitor, 21-aminosteroid (21-AS) and fluid-alkaline-mannitol (FAM) diuresis with either of them alone to determine the effic...

Membrane lipid peroxidation processes yield products that may react with DNA and proteins to cause oxidative modifications. The oxyR gene product regulates the expression of enzymes and proteins that are needed for cellular protection against oxidative stress. Upon exposure to tert-butylhydroperoxide (t-BOOH) and 2,2'-azobis (2-amidinopropane) hydrochloride (AAPH), which induce lipid peroxidati...

       This study was designed to explore the protective effects of ascorbic acid and water extract of Spirulina platensis (blue green algae) on methotrexate-induced lipid peroxidation using goat liver as the lipid source. This in vitro evaluation was done by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide content of tissue homogenates....

objective(s): bone marrow mesenchymal stem cells (mscs) play an important role in bone health. cadmium causes osteoporosis, but the exact mechanisms of its effect on mscs are not known. materials and methods: rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and morphological studies on mscs were carried out as a cellular backup for oste...

oxidation of low density lipoprotein (ldl) particles plays a key role in the etiology of atherosclerosis and coronary artery disease (cad). oxidative stress enhances the likelihood of ldl oxidation and atherosclerotic plaque development. paraoxonase (poni) is an enzyme associated with hdl that metabolizes organophosphates and has antioxidant activity. in order to investigate the relationship be...

fenpropathrin is a new pyrethroid insecticide used to control crop pests. the aim of this study was to evidence fenpropathrin-induced oxidative stress and alterations in biochemical parameters in the freshwater fish, alburnus mossulensi s. total antioxidant capacity, malondialdehyde (mda), catalase activity (cat), aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosph...

diazinon is an organophosphate which is extensively used in trade and agriculture. due to its widespread application, its toxicity is common. several studies have shown that organophosphates are able to induce oxidative stress by generating free radicals and depletion of endogenous antioxidants. pomegranate seed oil (pso) possesses anti-inflammatory and antioxidant effects. in this study, the e...

t-2 toxin, a trichothecene mycotoxin, is considered to be one of the most toxic compounds that are produced by molds, particularly the fusarium species. fusarium species have been recognized as a great agricultural problem. they occur worldwide on a variety of plant hosts and cereal grains. the aim of this study was to investigate t-2 toxin-induced liver injury using in situ perfused rat liver....