diazinon (dzn) is a synthetic organophosphorus (ops) insecticide widely used in agricultural and household applications. ops, particularly dzn, are highly lipid soluble liquids. intravenous lipid emulsion (ile) has been shown to reduce toxicity caused by some lipid soluble agents. we evaluated the antidote effect of ile on acute toxicity of dzn. twenty-four sprague-dawley female rats weighting ...

objective(s): the increasing use of methamphetamine (meth) in the last decades has made it the second most abused drug. advancs in the area of intravenous lipid emulsion (ile) have led to its potential application in the treatment of poisoning. the present study aims to investigate the potential role of ile as an antidote for acute meth poisoning. materials and methods: two groups of six male r...

to evaluate the effect of intravenous infusion of a soybean based lipid emulsion (lipovenoes 10%) on some blood constituents in sheep, a replicated 2 × 2 latin square design experiment was conducted in four clinically healthy ewes. lipid emulsion (le group) or normal saline (ns group) was infused intravenously at a rate of 0.025 ml kg-1 per min for 6 hr and the concentrations of blood triglycer...

We present a case of refractory cardiogenic shock secondary to sustained release diltiazem poisoning.  Intravenous lipid emulsion therapy was initiated approximately 13 hours after ingestion. Vasopressors were weaned off hours after initiation of intravenous lipid emulsion therapy and the patient went on to make a full recovery.  This report adds to the paucity of data on intravenous lipid emul...

STUDY OBJECTIVES Lipid emulsions have been suspected of inducing certain modifications in gas exchange and pulmonary hemodynamics. The aim of this prospective study was to evaluate the hemodynamic and pulmonary effects of two lipid emulsions. DESIGN Prospective, randomized, double-blind, crossover study. SETTING Medical and surgical ICU in a French university hospital. PATIENTS Eighteen p...

BACKGROUND The goal of this in vitro study was to investigate the effect of lipid emulsion on vasodilation caused by toxic doses of bupivacaine and mepivacaine during contraction induced by a protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), in an isolated endothelium-denuded rat aorta. METHODS The effects of lipid emulsion on the dose-response curves induced by bupivacaine o...

BACKGROUND Soybean oil lipid emulsion may compromise immune function and promote hepatic damage due to its composition of long-chain fatty acids, phytosterols, high proportion of ω-6 fatty acids, and low α-tocopherol levels. Combination lipid emulsions have been developed using medium-chain triglyceride oil, fish oil, and/or olive oil, which provide adequate essential fatty acids, a smaller con...

Intravenous lipid emulsion is an established, effective treatment for local anesthetic-induced cardiovascular collapse. The predominant theory for its mechanism of action is that by creating an expanded, intravascular lipid phase, equilibria are established that drive the offending drug from target tissues into the newly formed 'lipid sink'. Based on this hypothesis, lipid emulsion has been con...

To investigate the molecular organization and phase behavior of physiologic lipid mixtures that contain either newly synthesized pseudoceramide or type III synthetic ceramide, various analytical techniques were used. The phase transition temperatures detected in differential scanning calorimetry analysis were 51.19 and 50.52 for the pseudoceramide-containing physiologic lipid mixture and synthe...

In a prospective, randomized clinical trial, the toxicity of 1 mg of amphotericin B (AmB) per kg of body weight per day infused in 5% dextrose was compared with that of AmB infused in lipid emulsion in children with malignant disease. In an analysis of 82 children who received a full course of 6 days or more of AmB (117 courses), it was shown that there were significant increases in plasma urea...