Protein and protein-lipid interactions, with and within specific areas in the cell membrane, are critical in order to modulate the cell signaling events required to maintain cell functions and viability. Biological bilayers are complex, dynamic platforms, and thus in vivo observations usually need to be preceded by studies on model systems that simplify and discriminate the different factors in...

background:the zinc-finger x linked (zfx) gene encodes a transcription factor that acts as a regulator of self-renewal of stem cells. due to the role of zfx in cell growth, understanding zfx protein-protein interactions helps to clarify its proper biological functions in signaling pathways. the aim of this study is to define zfx protein-protein interactions and the role of zfx in cell growth. m...

BACKGROUND Protein-lipid interactions play essential roles in the conformational stability and biological functions of membrane proteins. However, few of the previous computational studies have taken into account the atomic details of protein-lipid interactions explicitly. RESULTS To gain an insight into the molecular mechanisms of the recognition of lipid molecules by membrane proteins, we i...

Surface plasmon resonance (SPR) is an established method for studying molecular interactions in real time. It allows obtaining qualitative and quantitative data on interactions of proteins with lipid membranes. In most of the approaches, a lipid membrane or a membrane-mimetic surface is prepared on the surface of Biacore (GE Healthcare) sensor chips HPA or L1, and the studied protein is then in...

data regarding the effects of dietary protein on modifying serum lipid and lipoprotein levels are controversial. in this study we have investigated the hypothesis whether dietary protein and protein to carbohydrate ratio could be related to subsequent changes in lipid profile in adults.this 3-yaers follow-up_longitudinal study was conducted on a sample of participants (845 men and 1043 women, a...