background: phthalates are a group of multifunctional chemicals. diethyl phthalate (dep) is one of the most frequently used phthalates in solvents and fixatives for numerous industrial products. method: the present experiment was designed to assess oxidative stress, if any, caused by diethyl phthalate. for this the homogenates of liver and kidney were treated with different concentrations ( 10-...

objective: the goal of the current research was to investigate the effect of aerobic exercise on c-reactive protein (crp) and lipid profile in overweight-obese women with subclinical hypothyroidism. methods: this study enrolled 23 women who suffered from subclinical hypothyroidism. patients' average age was 41.08±6.56 years and bmi was >25 kg/m2. subjects, following medical screening, were obje...

plant lipid transfer proteins (ltps) are members of the pathogenesis-related proteins (pr-14) and some of them exhibit activity against phytopathogenic fungi. to investigate whether rice ltp2 plays a role in antifungal activity, the coding region of an iranian rice ltp2 gene was cloned into expression vector pet24-d(+) and then expressed in escherichia coli rosetta strain (de3). the potential a...

Published studies of lipid-protein interactions have mainly focused on lipid binding to an individual site of the protein. Here, we show that a lipid can migrate between different binding sites in a protein and this migration modulates protein function. Voltage-gated potassium (Kv) channels have several potential binding sites for phosphatidylinositol-4,5-bisphosphate (PIP2). Our molecular dyna...

conclusions contrast-agent-induced nephropathic changes are more closely related to the magnitude of lipid peroxidation than protein oxidation. results compared with the control group, groups cin and n + cin had significantly higher urea and lhp levels (p < 0.05 and p < 0.001, respectively) and significantly lower cu, zn-sod activity and creatinine clearance (p < 0.05). there was no statistical...

Membranes do not only provide a matrix for variety of chemical reactions mediated by membrane proteins, but also actively participate in the regulation protein structure and function. We conducted molecular dynamics simulations to investigate how lipid-protein interactions affect function case MthK, potassium channel. constructed different bilayers test effects thickness, cholesterol content, u...

Membrane proteins and membrane lipids are frequently organized in submicron-sized domains within cellular membranes. Factors thought to be responsible for domain formation include lipid-lipid interactions, lipid-protein interactions and protein-protein interactions. However, it is unclear whether the domain structure is regulated by other factors such as divalent cations. Here, we have examined...

For four decades, since W. Helfrich's pioneering study of smectic A liquid crystals in 1973, continuum elastic models (CEMs) have been employed as tools to understand the energetics of protein-induced lipid bilayer deformations. Among the assumptions underlying this use is that all relevant protein-lipid interactions can be included in the continuum representation of the protein-bilayer interac...

The plasma membrane is an important organelle providing structure, signaling and transport as major biological functions. Being composed of lipids and proteins with different physicochemical properties, the biological functions of membranes depend on specific protein-protein and protein-lipid interactions. Interactions of proteins with their specific sterol and lipid environment were shown to b...