our prior study found  that transforming growth factor  beta-induced (tgfbi) is  an important negative regulator in tlr-induced inflammation. however, whether tgfbi may affect inflammation during lipopolysaccharide (lps)-induced endotoxin tolerance (et) is still unclear.this study aimed to investigate whether tgfbi was involved in the mechanisms of et in human through dampening nuclear factor-k...

To investigate the protective effect of quercetin on lipopolysaccharide-induced inflammatory response retinal ganglion cell line 5 cells and to explore its possible molecular mechanism. Retinal were cultured in vitro assigned into blank control group, lipopolysaccharide (1.0 μg/ml) induction lipopolysaccharide+low dose (0.25 lipopolysaccharide+medium (0.5 group lipopolysaccharide+high group. Th...

To investigate the effects and mechanisms of Dexmedetomidine on inflammatory factors mitogenactivated protein kinase related signaling pathways in alveolar lavage fluid mice with acute lung injury induced by lipopolysaccharide. 36 clean-grade male Kunming were randomly divided into blank control group (normal group), lipopolysaccharide-induced model group, lipopolysaccharide+dexmedetomidine 12 ...

background: the contribution of neuroinflammation in alzheimer’s disease (ad) has been widely reported. the effects of female gonadal hormones in both neuroinflammation and brain cognitive functions have also been well considered. objectives: in the present study, the possible protective role for endogenous ovarian hormones against learning and memory impairment as well as brain tissues oxidati...

background and aims: several studies have shown that there is greater number of viruses in deep periodontal pockets than in normal gingival sulcus. we also know that virus may have an important role in induction of il-1β secretion by different human cells. in this study we intended to determine the capacity of herpes simplex virus type 1 to stimulate il-1β secretion in human gingival keratinocy...

objective(s): in the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (egcg) on lipopolysaccharide (lps)-induced hepatotoxicity by using hep3b human hepatoma cells. specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of lps-associated cytotoxicity. consequently, the hepatocellu...

the present study investigated the effects of e. coli lipopolysaccharide (lps) induced mastitis model in rat on the activity of antioxidant enzyme systems. to achieve this purpose, e. coli lps were infused into the mammary gland of 12 rats 72 hr postpartum and compared with 12 rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. the antioxidant activ...

objective: astrocytes are the most abundant glial cell type. they may promote or inhibit cns inflammation depending on which cytokines are secreted. astrocytes also have immune roles. il-19, il-20, and il-24 activate a heterodimer receptor composed of the il-20r1 α-chain and the il-20r2 β-chain. it has long been considered that signaling by these receptor complexes affects immunological reactio...

We use comparable micro level panel data for 14 countries and a set of identically specified empirical models to investigate the relationship between exports and productivity. Our overall results are in line with the big picture that is by now familiar from the literature: exporters are more productive than non-exporters when observed and unobserved heterogeneity is controlled for, and these ex...

brain derived neurotrophic factor (bdnf) is a neurotrophin acting at several levels in the brain. additionally, bdnf was shown to be responsible for the survival, maintenance and growth of neurons. also, bdnf plays an important role in synaptic plasticity and memory processes. in activity-dependent synaptic plasticity, bdnf enhances long-term potentiation (ltp) in the hippocampus but blocks the...