Background: Macrophages activation is the important anti-leishmania immune response. Different signals could affect macrophages development and functional activation. Objectives: In the present study, we compared the effect of Leishmania Soluble Antigen (LSA)and Lipopolysaccharide (LPS) on peritoneal macrophage responses. Appropriate activation of macrophages depends on thesignals they receive ...

introduction: lishmania is a protozoan parasite that cause visceral and cutaneous disease in man. this parasite shows two forms in its life cycle, amastigote in reticulo-endothelial cell of mammalian host and, promastigote in culture media and sand fly vector. like other kinetoplastide, leishmania has an extra chromosomal dna with unique topological and characteristic that called kdna. the orga...