DESCRIPTION LOPID (gemfibrozil tablets, USP) is a lipid regulating agent. It is available as tablets for oral administration. Each tablet contains 600 mg gemfibrozil. Each tablet also contains calcium stearate, NF; candelilla wax, FCC; microcrystalline cellulose, NF; hydroxypropyl cellulose, NF; hypromellose, USP; methylparaben, NF; Opaspray white; polyethylene glycol, NF; polysorbate 80, NF; p...

Introduction: Hyperlipidemia is one of the most important and common risk factors of cardiovascular diseases especially Atherosclerosis and consequently CHD. Unalike age and gender, hyperlipidemia is a factor which can be controlled by altering the life style, nutritional habits and medical-medicinal interventions. Although serum level of cholesterol is always noticed in hyperlipidemia, hypertr...

Introduction: Hyperlipidemia is one of the most important and common risk factors of cardiovascular diseases especially Atherosclerosis and consequently CHD. Unalike age and gender, hyperlipidemia is a factor which can be controlled by altering the life style, nutritional habits and medical-medicinal interventions. Although serum level of cholesterol is always noticed in hyperlipidemia, hypertr...

Objective— 1-Antitrypsin (AAT) protects elastic tissue and may play a role in atherogenesis. The association of atherosclerosis progression with common AAT variants was considered in 2 clinical trials. Methods and Results—We examined the association of AAT V213A, S and Z deficiency alleles, and the functional 3 UTR 11478G A with change in minimal luminal diameter, a measure of focal disease, in...

Animal and human studies support a role for apolipoprotein A-V (apoA-V) in triglyceride (TG) metabolism. We examined the relationship of APOA5 -1131T>C and S19W with lipid subfractions and progression of atherosclerosis in the Lopid Coronary Angiography Trial. Compared with -1131TT men (n = 242), carriers of the -1131C allele (n = 54) had significantly higher total TG (P = 0.03), reflected in s...

OBJECTIVE Alpha1-Antitrypsin (AAT) protects elastic tissue and may play a role in atherogenesis. The association of atherosclerosis progression with common AAT variants was considered in 2 clinical trials. METHODS AND RESULTS We examined the association of AAT V213A, S and Z deficiency alleles, and the functional 3' UTR 11478G>A with change in minimal luminal diameter, a measure of focal dise...

BACKGROUND Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the expression of genes involved in lipid metabolism and inflammation, making it a candidate gene for atherosclerosis and ischemic heart disease (IHD). METHODS AND RESULTS We investigated the association between the leucine 162 to valine (L162V) polymorphism and a G to C transversion in intron 7 of the PPARalpha...

Gemfibrozil more potently inhibits CYP2C9 than CYP2C8 in vitro, and yet the opposite inhibitory potency is observed in the clinic. To investigate this apparent paradox, we evaluated both gemfibrozil and its major metabolite, an acyl-glucuronide (gemfibrozil 1-Oglucuronide) as direct-acting and metabolism-dependent inhibitors of the major drug-metabolizing cytochrome P450 enzymes (CYP1A2, 2B6, 2...