background: regular aerobic exercise improves the background: regular aerobic exercise improves the inflammatory status in different lung diseases. however, the effects of long-term aerobic exercise on the lung response have not been investigated. the present study evaluated the effect of aerobic exercise on the lung inflammatory. m aterials and methods: 12 adult male wistar rats were divided t...

objective(s):therapies with high levels of oxygen are commonly used in the management of critical care. however, prolonged exposure to hyperoxia can cause acute lung injury. although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (hali).   materials a...

experimental evidence suggested that sodium ferulate (sf) and oxymatrine (omt) combination had synergistic anti-inflammatory and antioxidant effects. we hypothesized that sf and omt combination treatment might have protective effects on paraquat-induced acute lung injury. in our study, the swiss mice were randomly divided into seven groups, including control, paraquat (pq), sf (6.2 mg/kg/day); ...

objective(s):bone marrow-derived mesenchymal stem cells (bmscs) have attracted significant interest to treat asthma and its complication. in this study, the effects of bmscs on lung pathology and inflammation in an ovalbumin-induced asthma model in mouse were examined. materials and methods:balb/c mice were divided into three groups: control group (animals were not sensitized), asthma group (an...

it was known that il-1β-induced rapid expression of mir-146a, which regulated the secretion of inflammatory chemokines in human a549 alveolar epithelial cells. however, little is known about the level of primary mir-146a and the downstream biogenesis of mir-146a in a549 cells. we examined the levels of primary mir-146a and mature mir-146a in a549 cells following treatment with pharmacological i...

Objective(s):One cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. It has been shown that Chinese green tea (CGT) (Lung Chen Tea) has higher antioxidant property than black tea. In this paper, we will explore the preventive effect of CGT on cigarette smoke-in...

objective(s):one cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. it has been shown that chinese green tea (cgt) (lung chen tea) has higher antioxidant property than black tea. in this paper, we will explore the preventive effect of cgt on cigarette smoke-in...

quercetin is a dietary flavonoid which has anti-inflammatory effects. this study aimed to evaluate the influence of quercetin on histopathological aspects and airway epithelium in  allergic airway  inflammation mice model. twenty-eight balb/c mice were randomly divided into four groups: group i (control), group ii (untreated mice with allergic airway inflammation), group iii (allergic airway in...

Objective(s): Cardiovascular disease has an important role in mortality caused by lung injury. Emphysema is associated with impaired pulmonary gas exchange efficiency and airflow limitation associated with small airway inflammation. The aim was to evaluate the interactions between lung injury, inflammation, and cardiovascular disease. Since gallic acid has antioxidant ...

introduction: the prevalence of allergic airway diseases has dramatically increased in recent years all over the world. murine models of allergic airway inflammation have provided helpful information about treatment and cellular and molecular mechanisms of the disease. previous published works using murine models to investigate latex allergy did not introduce a complete characteristic eosinophi...