background & objectives: chronicity of lupus nephritis (ln) should be considered for interaction of cell mediated immunity (cmi) and dendritic cells in glomeruli and tubulointerstitial areas. in this study establishment of immunohistopathological changes of dendritic cells and other immune effector cells in lupus nephritis comparing with non-lupus nephritis was performed. materials & m...

abstract background: the prognosis of sle is int1uenced by the onset of glomerulonephtitis. clinical ttials in lupus nephritis have demonstrated that cyclophosphamide therapy is the superior regimen in the management oflupus nephritis for preserving renal function. objective: the purpose of this study is to define the outcome of renal function with bolus pu lses of cyclophosphamide and steroid ...

PURPOSE OF REVIEW A combination of systemic autoimmunity and tissue response to immune injury underlie renal involvement in lupus erythematosus. In this review, we discuss recent literature investigating pathogenetic mechanisms of lupus glomerulonephritis. RECENT FINDINGS In lupus glomerulonephritis, glomerular immune complexes were believed to be the primary mediators of renal disease. Recen...

Twenty-seven patients with histologically confirmed lupus nephritis were studied to identify the incidence of lupus band and its significance to histological patterns of nephritis and complement levels. It was found that the kidney involvement is 2.5 times more frequent in lupus band positive patients. The association of a positive lupus and low C3 level signifies the presence of diffuse prolif...

Immune complex 'lupus-like glomerulonephritis' is a type of renal injury seen infrequently in human immunodeficiency virus (HIV) patients and very little is known about the clinical course and treatment. Treatment options are limited but antiretroviral therapy and steroids have been tried with limited success. We report a case of a 21-year-old HIV-positive African American male with lupus-like ...

BACKGROUND AND OBJECTIVES Lupus nephritis is a classic immune complex glomerulonephritis. In contrast, antineutrophil cytoplasmic antibodies are associated with necrotizing and crescentic glomerulonephritis, in the absence of significant immune deposits. Antineutrophil cytoplasmic antibodies are detected by indirect immunofluorescence in 20% of patients with systemic lupus erythematosus. We rep...

Antiretroviral therapy (ART) has increased the life expectancy of human immunodeficiency virus (HIV) infected patients. However, the incidence of kidney diseases in HIV-infected patients has increased. Before the ART era, HIV-associated nephropathy (HIVAN) was the most common type of glomerulonephritis in HIV-related kidney diseases, but after the advent of ART, many other types of glomerulonep...

Background & Objectives: Chronicity of lupus nephritis (LN) should be considered for interaction of cell mediated immunity (CMI) and dendritic cells in glomeruli and tubulointerstitial areas. In this study establishment of immunohistopathological changes of dendritic cells and other immune effector cells in lupus nephritis comparing with non-lupus nephritis was performed. Materials & Methods: ...

Consecutive renal biopsies received from 1994 to 2000 in Johor Bahru were reviewed. There were 441 cases, of which 407 were adequate biopsies (92.3%). Lupus nephritis formed the largest diagnostic entity (126 cases, 31.0%). This reflected the high prevalence of systemic lupus erythematosus (SLE) patients in Malaysia. The most common histological pattern of lupus nephritis was diffuse proliferat...