نتایج جستجو برای: M5’

تعداد نتایج: 3415  

2007
Makoto Sakaguchi Kentaroh Yoshida

We study intersecting noncommutative (NC) M5-branes from κ-invariance of an open supermembrane action with constant three-form fluxes. The κ-invariance gives rise to possible D-brane configurations for which projection operators can be determined. We construct projection operators for two types of 1/4 BPS intersecting NC M5-branes. The one is an intersection of two NC M5-branes: NC M5⊥NC M5 (3)...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Anthony S Basile Irina Fedorova Agustin Zapata Xiaoguang Liu Toni Shippenberg Alokesh Duttaroy Masahisa Yamada Jurgen Wess

Little is known about the physiological roles of the M5 muscarinic receptor, the last member of the muscarinic receptor family (M1-M5) to be cloned. In the brain, the M5 receptor subtype is preferentially expressed by dopaminergic neurons of the substantia nigra and the ventral tegmental area. Dopaminergic neurons located in the ventral tegmental area are known to play important roles in mediat...

2011
Simone Tomasi Paolo Sarmientos Giada Giorda Victor Gurewich Alessandro Vercelli

A single-site mutant (M5) of native urokinase plasminogen activator (prouPA) induces effective thrombolysis in dogs with venous or arterial thrombosis with a reduction in bleeding complications compared to tPA. This effect, related to inhibition of two-chain M5 (tcM5) by plasma C1-inhibitor (C1I), thereby preventing non-specific plasmin generation, was augmented by the addition of exogenous C1I...

Journal: :Cancer research 1983
M D'Incalci L Torti G Damia E Erba L Morasca S Garattini

Resistance of mouse M5076 (M5) ovarian reticular cell sarcoma to cyclophosphamide (CTX) was obtained in vivo by repeated drug treatment followed by transplantation of the regrowing tumor. After 16 passages, we obtained an M5 subline resistant to CTX (M5-CTX-16R). Median survival times were approximately 29 and 39 days for M5 and M5-CTX-16R, respectively. Survival of M5-bearing mice given a sing...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Daniel J Foster Patrick R Gentry Jose E Lizardi-Ortiz Thomas M Bridges Michael R Wood Colleen M Niswender David Sulzer Craig W Lindsley Zixiu Xiang P Jeffrey Conn

Of the five muscarinic receptor subtypes, the M5 receptor is the only one detectable in midbrain dopaminergic neurons, making it an attractive potential therapeutic target for treating disorders in which dopaminergic signaling is disrupted. However, developing an understanding of the role of M5 in regulating midbrain dopamine neuron function has been hampered by a lack of subtype-selective comp...

2014
Patrick R. Gentry Masaya Kokubo Thomas M. Bridges Meredith J. Noetzel Hyekyung P. Cho Atin Lamsal Emery Smith Peter Chase Peter S. Hodder Colleen M. Niswender J. Scott Daniels P. Jeffrey Conn Craig W. Lindsley Michael R. Wood

A functional high throughput screen identified a novel chemotype for the positive allosteric modulation (PAM) of the muscarinic acetylcholine receptor (mAChR) subtype 5 (M5). Application of rapid analog, iterative parallel synthesis efficiently optimized M5 potency to arrive at the most potent M5 PAMs prepared to date and provided tool compound 8n (ML380) demonstrating modest CNS penetration (h...

Journal: :The Journal of Experimental Medicine 1983
J B Dale J M Seyer E H Beachey

We determined the antigenic specificity and protective immunogenicity of two chemically synthesized peptides of type 5 streptococcal M protein. The synthetic peptides, designated S-M5(1-20) and S-M5(20-40), represent the amino-terminal amino acid sequence of the native pepsin-extracted M5 molecule, which is known to contain at least one heart cross-reactive epitope. Initial studies showed that ...

Journal: :Circulation research 2002
Jian-Ning Liu Jian-Xia Liu Bei-fang Liu Bf Ziyong Sun Jian-Ling Zuo Pei-xiang Zhang Px Jing Zhang Yu-hong Chen Yh Victor Gurewich

Prourokinase (proUK) is a zymogenic plasminogen activator that at pharmacological doses is prone to nonspecific activation to urokinase. This has handicapped therapeutic exploitation of its fibrin-specific physiological properties. To attenuate this susceptibility without compromising specific activation of proUK on a fibrin clot, a Lys300-->His mutation (M5) was developed. M5 had a lower intri...

Journal: :Chemical senses 2006
Makoto Ohmoto Ichiro Matsumoto Takumi Misaka Keiko Abe

Two voltage-dependent potassium channels, KCNQ1 and KCNH2, are expressed in the taste buds and were identified as strong candidates involved in the repolarization of taste receptor cells expressing phospholipase C-beta2 and TRPM5 (beta2/M5-TRCs). In cell type-specific expression, KCNQ1 was expressed in most taste bud cells, including beta2/M5-TRCs, whereas KCNH2 was expressed in a subset of bet...

2014
Rui Zhang Ji-Yun Lee Xianfu Wang Weihong Xu Xiaoxia Hu Xianglan Lu Yimeng Niu Rurong Tang Shibo Li Yan Li

To assess the possible existence of unbalanced chromosomal abnormalities and delineate the characterization of copy number alterations (CNAs) of acute myeloid leukemia-M5 (AML-M5), R-banding karyotype, oligonucelotide array CGH and FISH were performed in 24 patients with AML-M5. A total of 117 CNAs with size ranging from 0.004 to 146.263 Mb was recognized in 12 of 24 cases, involving all chromo...

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