The inherent mobility of mobility devices is replacing the fixed work environments, making such devices a kind of indispensable good, both personally and professionally. The rise of Web 2.0 allows user interaction and collaboration, employing, for instance, web applications in mobile devices. Today, SOA (Service Oriented Architecture) is the most widely adopted paradigm for development of distr...

Metaplastic breast cancer (MBC) is a malignancy characterized by the histologic presence of two or more cellular types, commonly a mixture of epithelial and mesenchymal components. MBC is rare relative to invasive ductal carcinoma (IDC), representing less than 1% of all breast cancers. Other than a lower rate of lymph node metastases, MBC tumors display poorer prognostic features relative to ID...

The epithelial-to-mesenchymal transition (EMT) is a vital control point in metastatic breast cancer (MBC). TWIST1, SNAIL1, SLUG, and ZEB1, as key EMT-inducing transcription factors (EMT-TFs), are involved in MBC through different signaling cascades. This updated meta-analysis was conducted to assess the correlation between the expression of EMT-TFs and prognostic value in MBC patients. A total ...

Adequate concentrations of beta-lactam antibiotics in cerebrospinal fluid (CSF) are difficult to achieve for meningitis caused by drug-resistant Streptococcus pneumoniae. Ceftriaxone in dosages of 150 or 400 mg/kg of body weight per day, given in one or two doses, was used for the treatment of experimental highly cephalosporin-resistant (MIC and MBC, 4 microg/ml) pneumococcal meningitis. The ba...

Echocardiographic data were analyzed in 555 patients undergoing mitral balloon commissurotomy (MBC). Patients were enrolled in the National Heart, Lung, and Blood Institute Balloon Valvuloplasty Registry from 24 centers. There were 456 women and 99 men with a mean age of 54 years. Before MBC the two-dimensional echocardiographic variables of mitral valve thickness, mobility, calcification, and ...

4-Methylbenzylidene-camphor (4-MBC) is an organic sunscreen that protects against UV radiation and may therefore help in the prevention of skin cancer. Recent results on the estrogenicity of 4-MBC have raised concerns about a potential of 4-MBC to act as an endocrine disruptor. Here, we investigated the direct interaction of 4-MBC with estrogen receptor (ER) a and ERb in a series of studies inc...

BACKGROUND The features related to the prognosis of patients with mucinous breast cancer (MBC) remain controversial. We aimed to explore the prognostic factors of MBC and develop a nomogram for predicting survival outcomes. METHODS The Surveillance, Epidemiology, and End Results (SEER) database was searched to identify 139611 women with resectable breast cancer from 1990 to 2007. Survival cur...

Basement membranes (BMs) are vital extracellular matrix sheets that both connect and separate different cells and tissues in all multicellular animals. BMs determine organ differentiation and homeostasis. The authors provide the first report linking teneurin, a phylogenetically conserved transmembrane receptor, to BM structure and function. They discovered that Caenorhabditis elegans teneurin, ...

Shuttling nuclear transport receptors mediate nucleocytoplasmic traffic through nuclear pore complexes (NPCs). Importin , the best studied receptor, is also a key regulator of cell cycle events from mitotic spindle assembly to nuclear envelope fusion and NPC assembly. Now, Lau, Delmar et al. show that a second import receptor, transportin, regulates the same set of mitotic assembly events, incl...

Measurement-based care (MBC) can be defined as the practice of basing clinical care on client data collected throughout treatment. MBC is considered a core component of numerous evidence-based practices (e.g., Beck & Beck, 2011; Klerman, Weissman, Rounsaville, & Chevron, 1984) and has emerging empirical support as an evidence-based framework that can be added to any treatment (Lambert et al., 2...