Abstract Matrix metalloproteinases (MMPs), a class of zinc-contained endopeptidases, are closely involved in tumor growth, infiltration, metastasis, and angiogenesis. By virtue the specifically enzymatic hydrolysis, MMPs have been widely used to turn on imaging and/or therapy function elaborately designed enzyme-responsive nanoprobes, which is expected realize precise diagnosis treatment cancer...

objective(s): epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as swi/snf. brg1 also known as smarca4 is a catalytic subunit of swi/snf, which is necessary for mmps expression. matrix metalloproteinases (mmps) are known as important player enzymes during tumor progression and metastasis. aberrant epigenetic modification of chromatin should be...

Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...

background increasing evidence indicates that opiate users and methadone maintenance patients (mmps) are impaired in executive control tasks and response inhibition behavior compared to healthy individuals; however, the cognitive functional difference between opiate addicts and mmps has not been clarified. objectives this study employed go/no-go tasks to evaluate the response inhibition behavio...

matrix metalloproteinases (mmps) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. mmps have been demonstrated to increase the permeability of the blood–brain barrier (bbb) by degrading the compone...

results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...

Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...