نتایج جستجو برای: MRL/lpr Mice

تعداد نتایج: 393032  

Journal: :Journal of the American Society of Nephrology : JASN 2006
Rahul D Pawar Prashant S Patole Daniel Zecher Stephan Segerer Matthias Kretzler Detlef Schlöndorff Hans-Joachim Anders

Viral infections may trigger immune complex glomerulonephritis via Toll-like receptors (TLR), as certain TLR trigger immunity upon recognition of viral nucleic acids. On the basis of previous findings regarding viral double-stranded RNA and TLR3 in experimental lupus erythematosus, a similar role for TLR7 that recognizes viral single-stranded RNA was hypothesized. Immunostaining of kidney secti...

2015
Bastian Schirmer Dirk Wedekind Silke Glage Detlef Neumann Pierre Bobé

The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRLlpr mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time...

2013
Simon J. Freeley Angela Giorgini Calogero Tulone Reena J. Popat Catherine Horsfield Michael G. Robson

Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation. Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4. We examined the role of these molecules in MRL lpr mice which is one of the most established and robust murine models. We compared disease parameters in Toll-like receptor 2 or Toll-like r...

Journal: :Biochemical pharmacology 2011
Yan Shen Qiong Luo Huimin Xu Fangyuan Gong Xiaobin Zhou Yang Sun Xuefeng Wu Wen Liu Guangzhi Zeng Ninghua Tan Qiang Xu

Facilitating T-cell apoptosis is implicated as an effective therapeutic strategy for treatment of T cell-mediated disease, including inflammatory bowel disease. Here, we report that astin C, a plant cyclopeptide isolated from the roots of Aster tataricus (Compositae), induced apoptosis of activated T cells in a mitochondria-dependent but Fas-independent manner in that such activity was still ob...

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