نتایج جستجو برای: MSU

تعداد نتایج: 928  

Journal: :Waste and Biomass Valorization 2022

Abstract Purpose This work studies the immobilization of two enzymes, alcohol dehydrogenase (ADH) and aldehyde (AldDH) both from Saccharomyces cerevisiae , which could be used to produce high value-added molecules carboxylic acids embedded in anaerobic digestate. Methods In particular, three mesoporous siliceous materials, with different specific surface areas pore sizes, (MSU-H, MSU-F MCF 0.75...

2015
Hyun Sook Hwang Chung Mi Yang Su Jin Park Hyun Ah Kim Ali Mobasheri

Monosodium urate (MSU) crystals, which are highly precipitated in the joint cartilage, increase the production of cartilage-degrading enzymes and pro-inflammatory mediators in cartilage, thereby leading to gouty inflammation and joint damage. In this study, we investigated the effect of MSU crystals on the viability of human articular chondrocytes and the mechanism of MSU crystal-induced chondr...

2013
Isabelle Allaeys François Marceau Patrice E Poubelle

INTRODUCTION Monosodium urate (MSU) microcrystals present in bone tissues of chronic gout can be ingested by nonprofessional phagocytes like osteoblasts (OBs) that express NLRP3 (nucleotide-binding domain and leucine-rich repeat region containing family of receptor protein 3). MSU is known to activate NLRP3 inflammasomes in professional phagocytes. We have identified a new role for NLRP3 couple...

2015
Francesco Taus Marilina B. Santucci Emanuela Greco Matteo Morandi Ivana Palucci Sabrina Mariotti Noemi Poerio Roberto Nisini Giovanni Delogu Maurizio Fraziano Thomas Jens Scriba

A safer and more effective anti-Tuberculosis vaccine is still an urgent need. We probed the effects of monosodium urate crystals (MSU) on innate immunity to improve the Bacille Calmette-Guerin (BCG) vaccination. Results showed that in vitro MSU cause an enduring macrophage stimulation of the anti-mycobacterial response, measured as intracellular killing, ROS production and phagolysosome maturat...

2011
Tae-Jin Ju Jin-Myoung Dan Young-Je Cho So-Young Park

The present study elucidated the effect of the selective inducible nitric oxide synthase (iNOS) inhibitor N(6)-(1-iminoethyl)-L-lysine (L-NIL) on monosodium urate (MSU) crystal-induced inflammation and edema in mice feet. L-NIL (5 or 10 mg/kg/day) was administered intraperitoneally 4 h before injection of MSU (4 mg) into the soles of mice hindlimb feet. Twenty-four hours after MSU injection, fo...

2015
Ashika Chhana Gerald Lee Nicola Dalbeth

BACKGROUND Gout is a chronic disease of monosodium urate (MSU) crystal deposition. Although hyperuricaemia is the central risk factor for development of gout, not all people with hyperuricaemia have subclinical MSU crystal deposition or indeed, symptomatic disease. The aim of this systematic literature review was to identify factors that contribute to MSU crystallization. METHODS A search was...

Journal: :Stroke 2015
Ritvij Bowry Stephanie Parker Suja S Rajan Jose-Miguel Yamal Tzu-Ching Wu Laura Richardson Elizabeth Noser David Persse Kamilah Jackson James C Grotta

BACKGROUND AND PURPOSE Faster treatment with intravenous tissue-type plasminogen activator (tPA) is likely to improve outcomes. Optimizing prehospital triage by mobile stroke units (MSUs) may speed treatment times. The Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit (BEST-MSU) study was launched in May 2014 using the first MSU in the United States to compare stroke management ...

Journal: :Journal of immunology 2017
Payel Sil Craig P Hayes Barbara J Reaves Patrick Breen Shannon Quinn Jeremy Sokolove Balázs Rada

Human neutrophils (polymorphonuclear leukocytes [PMNs]) generate inflammatory responses within the joints of gout patients upon encountering monosodium urate (MSU) crystals. Neutrophil extracellular traps (NETs) are found abundantly in the synovial fluid of gout patients. The detailed mechanism of MSU crystal-induced NET formation remains unknown. Our goal was to shed light on possible roles of...

Journal: :Journal of nanoscience and nanotechnology 2010
Hyung Ik Lee Jin Hoe Kim Ji Man Kim Seok Kim Jung-Nam Park Jae Sik Hwang Jei-Won Yeon Yongju Jung

Ordered nanoporous silica (MSU-H) with high surface area has been utilized as a solid substrate of a surface-modified hybrid sorbent for the application to the removal of U(VI). Carboxymethylated polyethyleneimine (CMPEI) with a strong complexing property has been introduced to the pore surface of MSU-H substrate. CMPEI-modified MSU-H (CMPEI/MSU-H) has been characterized by scanning electron mi...

2017
Hanif J. Khameneh Adrian W. S. Ho Federica Laudisi Heidi Derks Matheswaran Kandasamy Baalasubramanian Sivasankar Gim Gee Teng Alessandra Mortellaro

Gouty arthritis results from the generation of monosodium urate (MSU) crystals within joints. These MSU crystals elicit acute inflammation characterized by massive infiltration of neutrophils and monocytes that are mobilized by the pro-inflammatory cytokine IL-1β. MSU crystals also activate the complement system, which regulates the inflammatory response; however, it is unclear whether or how M...

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