The male genital tract is considered an anatomical reservoir during therapy for human immunodeficiency virus infection, because the blood-testis barrier may prevent antiretroviral drugs (e.g., the protease inhibitors ritonavir, saquinavir and nelfinavir) from entering the male genital tract. To our knowledge, there are currently no available data on the penetration of the nucleoside analogue ab...

Human immunodeficiency virus type 1 (HIV-1) in the male genital tract may comprise virus produced locally in addition to virus transported from the circulation. Virus produced in the male genital tract may be genetically distinct, due to tissue-specific cellular characteristics and immunological pressures. HIV-1 env sequences derived from paired blood and semen samples from the Los Alamos HIV S...

Because semen is a major vehicle for the sexual transmission of HIV-1, control of viral replication within the sanctuary of the male genital tract should be a goal of antiretroviral therapy. Local immune responses, virus specific factors, and the degree of viral and cellular trafficking all appear to be important in controlling viral replication and evolution. However, the most important factor...

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital ...

the results of 10 year clinico - pathologic study about female genital tuberculosis in isfahan are reported. the main aims of this investigation were to study and review the tuberculosis of female genital tract to evaluate the influence of treatment and above all, to attempt to gain a better insight into the relation of infertility to this disease. in this study the following points have been t...

this study was carried out to compare the histomorphological structures of oviductal regionsof the apparently healthy adult laying hens (gallus gallus dometicus) and ducks (ansa ansadomesticus). for this purpose, 20 hens and 20 female ducks aged between 1–1.5 years were used.after euthanasia, the oviducts were dissected out and all of the gross morphometrical parametersincluding length, width a...

BACKGROUND The male genital tract is suspected to constitute a viral sanctuary as persistent HIV shedding is found in the semen of a subset of HIV-infected men receiving effective antiretroviral therapy (HAART). The origin of this persistent shedding is currently unknown. Phylogenetic studies indicated that HIV in semen from untreated men arises from local sources and/or passive diffusion from ...