matrix metalloproteinases (mmps) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. mmps have been demonstrated to increase the permeability of the blood–brain barrier (bbb) by degrading the compone...

background: one of the most major obstacles of ovarian tissue vitrification is suboptimal developmental competence of follicles. matrix metalloproteinases 2 (mmp-2) and 9 (mmp-9) and their tissue inhibitors timp-1 and timp-2 are involved in the remodeling of the extracellular matrix in the ovaries. objective: this study aimed to evaluate the expression of mmp-2, mmp-9, timp-1, and timp-2 genes ...

objective(s) the aim of the present study was to compare the therapeutic indices of several agents used in treatment of inflammatory conditions which included: vitamin e, hydro-alcoholic extracts of glycyrrhiza glabra, matricaria aurea, dexamethasone, piroxicam and diclofenac using wehi-164 fibrosarcoma cells. materials and methods cytotoxicity evaluation was based on vital dye exclusion assay....

although pyrimethamine (tindurin™) appears to be effective in the prevention and treatment of some infectious diseases, very little information exists on its unpredictable properties. we design this study to evaluate its anti-tumoral effect on a model of cell line. methods: the cytotoxic influence of pyrimethamine on prostate cell line was investigated using an in vitro colometric assay. the po...

results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...

effects of doxycycline on cx43 distribution and cardiac arrhythmia susceptibility of rats after myocardial infarction abstract: this study aimed to observe the effects of doxycycline (dox) on gap junction remodeling after mi and the susceptibility of rats to cardiac arrhythmia. the proximal left anterior descending coronary artery of rats was ligated to establish a myocardial infarction animal ...

objective: diabetes plays an important role in the progression of tissue damage. influencing factors of the cellular matrix can lead to changes in the structure and function of tissues or their failure. herbal consumption can be effective in reducing tissue failure. the aim of the this study is to research the effect portulaca oleracea seeds on the levels of matrix metalloproteinase 2, 9 and ti...