The yeast strains that are resistant to high concentration of ethanol have biotechnological benefits and aresuitable models for physiology and molecular genetics research fields. A novel ethanol-tolerant mutant strain,mut1, derived from the commercial Saccharomyces cerevisiae showed higher ethanol production, and alsodemonstrated resistance to ethanol but not to other alcohols...

Apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. It is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal DNA fragmentation. Although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription. Central metabolic pathways are under the control of signalling pathways and, vice versa, the cellular metabolic profile influences cell signalling through the incorporation of various metabolic sensors into the signalling networks. Thus information about nutrients availability...

apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. it is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal dna fragmentation. although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...

hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. recent research has increased our understanding of this pathway and its relation to other signalling pathways. in addition, a large number of studies confirmed the alterati...

Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk of an increasing number of human cancers. The predicted economic burden is causing significant concern. This has prompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number of metabolic processes and associated signalling pathways are asso...

fenugreek (trigonella foenum-graecum l.) has a long and respected history of medicinal uses in middle east and persian medicine. the hypocholesterolaemic and hypoglycaemic effects of fenugreek were attributed to its major steroidal sapogenin, diosgenin and its major alkaloid, trigonelline. the knowledge of diosgenin and trigonelline biosynthesis is derived from studies of cholesterol and nicoti...

Background: A prerequisite for successful embryo implantation is adequate preparation of receptive endometrium and the establishment and maintenance of a viable embryo. The success of implantation further relies upon a two-way dialogue between the embryo and uterus. However, molecular bases of these preimplantation and implantation processes in humans are not well known. Materials and Methods: ...