introduction: a factor known to cause thrombophilia in women with recurrent pregnancy loss (rpl) is the a1298c polymorphism of methylenetetrahydrofolate reductase gene (mthfr). this study aimed to determine the association between rpl and this polymorphism in iranian patients. methods: in this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...

introduction: one factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (rsa) is c677t polymorphism of methylenetetrahydrofolate reductase gene. this study aimed to determine the association between rsa and mthfr c677t polymorphism in iranian patients. methods: in this case-control study, 30 patients with previous history of two or more consecutive unexpla...

background recurrent pregnancy loss (rpl) is a serious problem for pregnancy. there is evidence that vascular complications play a principal role in rpl. methylenetetrahydrofolate reductase (mthfr) is a key enzyme in folate metabolism. polymorphisms (c677t, a1298c) of mthfr gene are associated with decreased mthfr activity. objectives the aim of this study was to determine the association betwe...

background: the association between methylene tetrahydrofolate reductase polymorphism and coronary artery diseases risk has been both confirmed and refuted in a number of published studies. the aim of this study was to investigate whether genetic polymorphisms of mthfr (c677t, a1298c) contributed to the development of myocardial infarction (mi). materials and methods: the present case-control s...

objective: the methylenetetrahydrofolate reductase (mthfr) gene polymorphism c677t is suspected to be a risk factor for psychiatric disorders, but it remains inconclusive whether the mthfr polymorphism c677t is imputed to vulnerability to schizophrenia and bipolar disorder. method: we prompted impetus to appraise this polymorphism in an iranian population. therefore, 90 patients with bipolar di...

background and aims. the aim of the present study is to determine the incidence of mthfr c677 t and a1298c mutations in iranian patients with cleft lip and/or cleft palate. materials and methods. we screened 61 iranian patients with cleft lip and/or cleft palate for mutations in the two alleles of mthfr gene associated with cleft lip and/or palate: a1298c and c677t, using polymerase chain react...

PURPOSE Data are conflicting concerning the risk for ischemic stroke associated with a common polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase C677T, which predisposes carriers to hyperhomocysteinemia. A meta-analysis study suggested that the 5,10-methylenetetrahydrofolate reductase 677TT genotype might have a small influence in determining susceptibility to ischemic s...

background: it is believed that environmental and genetic factors may be responsible for autism. methylenetetrahydrofolate reductase (mthfr) and its gene polymorphisms have been shown to be implicated as risk factors in autism. objectives: to analyze mthfr c677t polymorphism (rs1801133) in autistic patients. materials and methods: this study was carried out in 2014 and 2015 in northern iran. on...

Background. To determine whether or not a moderate genetic defect of homocysteine metabolism is associated with the development of coronary artery disease, we studied the prevalence of thermolabile methylenetetrahydrofolate reductase, which is probably the most common genetic defect of homocysteine metabolism. Methods and Results. Three hundred thirty-nine subjects who underwent coronary angiog...

background: attempts for early detection of gastric cancer have recently focused on host's genetic susceptibility factors and gene-environment interactions. we have, herein, studied the association of mthfr c677t single nucleotide polymorphism (snp) and its interaction with helicobacter pylori infection, smoking, age and gender on the risk of gastric cancer among an iranian population. met...