OBJECTIVES To determine whether a combination of ciprofloxacin hydrochloride and metronidazole hydrochloride would be as effective or more effective than a combination of gentamicin sulfate and metronidazole hydrochloride for preventing infection in patients with penetrating abdominal trauma, to evaluate the factors associated with increased risk of infection, and to determine the serum peak an...

Palonosetron hydrochloride is a relatively long-acting selective 5-HT3 receptor antagonist that has been approved for the prevention of chemotherapy-induced nausea and vomiting and is being evaluated for the prevention of postoperative nausea and vomiting. The objective of this study was to evaluate the physical and chemical stability of palonosetron hydrochloride 50 mcg/mL when mixed with gent...

OBJECTIVE New drugs have to be assessed in endodontic therapy due to the presence of microorganisms resistant to therapeutic procedures. Thus, this study evaluated the time- and concentration-dependent cytotoxicity of different antibiotics used in endodontic therapy. MATERIAL AND METHODS Human gingival fibroblasts were treated and divided into the following experimental groups: Group I - cont...

This study has selected the medium-chain saturated fatty acid pelargonic as raw material for first time, and added surface catalyst Tween 80 to aqueous solution form acid–Tween composite vesicles by a tension method. The compound vesicle was used encapsulate five heterocyclic drugs (cefazolin sodium, chlorpromazine hydrochloride, gemcitabine metronidazole, isoniazid), all of which have disadvan...

An amoeba of the genus Naegleria causing fatal meningoencephalitis in a human subject has been investigated for its sensitivity to several drugs. Penicillin, sulphadiazine, chloramphenicol, oxytetracycline hydrochloride, streptomycin, methotrexate, emetine, quinine, and metronidazole had no effect on the organism in vitro at levels in excess of those likely to be attained therapeutically in the...

Ellis BW. Symptomatic treatment of primary pneumatosis coli with metronidazole. Br Med J 1980 ;280 :763-4. 2 Down RHL, Castleden WM. Oxygen therapy for pneumatosis coli. Br MedJ3 1975;i:493-4. Andersen JB, Olesen KP, Eikard B, Janser E, Qvist J. Periodic continuous positive airway pressure, CPAP, by mask in the treatment of atelectasis. EurJ_ Respir Dis 1980;61:20-5. Edwards G, Leszczynski SO. ...

Metronidazole and niridazole combined with dehydroemetine in treatment of children with amoebic liver abscess. Metronidazole combined with dehydroemetine cured 13 of 15 children with amoebic liver abscess. An alternative combination of niridazole with dehydroemetine produced cure in 13 of 14 children. No relapses were observed. Electrocardiographic changes were noted in 2 of the first group and...

SYNOPSIS An amoeba of the genus Naegkeria causing fatal meningoencephalitis in a human subject has been investigated for its sensitivity to several drugs. Penicillin, sulphadiazine, chloramphenicol, oxytetracycline hydrochloride, streptomycin, methotrexate, emetine, quinine, and metronidazole had no effect on the organism in vitro at levels in excess of those likely to be attained therapeutical...

spectrophotometric and electrochemical studies were successfully used in quantitative analysis of amitriptyline hydrochloride (ath) and nortriptyline hydrochloride (nth). conductometric titration were carried out in equeous solution using iodide and dopamine and serotonine as titrant. two new methods using spectrophotometry are dascribed for the determination of (ath) and (nth) with potassium b...

BACKGROUND Lyme disease in humans is predominantly treated with tetracycline, macrolides or beta lactam antibiotics that have low minimum inhibitory concentrations (MIC) against Borrelia burgdorferi. Horses with Lyme disease may require long-term treatment making frequent intravenous or intramuscular treatment difficult and when administered orally those drugs may have either a high incidence o...