Abstract: In this review we have elaborated about number of hypothesis postulated to understand the mechanism hydrotropic agents, although majority haven’t justified solubility enhancement mechanism. Further it articles focuses upon parameters affecting solubilizing ability. Hydrotropes are extensively used in drug solubilization, extraction agents for various phytoconstituents, separation agen...

aceclofenac is a non-steroidal anti-inflammatory drug (nsaid) that exhibits analgesic, antipyretic and anti-inflammatory activities. it is practically insoluble in water. the effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. the enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

Highly hydrophilic counterions such as sodium or chloride are not good choices to achieve efficient hydrotropy.