high-dose chemotherapy and autologous stem cell transplantation (sct) have become an effective care for many patients with hematological malignancies. harvesting the stem cells is one the most important parts of sct. the two most commonly used mobilization regimens are the use of granulocyte colony-stimulating factor (g-csf) or g-csf plus chemotherapy. however, about 10-30% of patients are unab...

peripheral blood stem cell transplantation (pbsct) is an effective treatment for hematological malignancies. mobilization of peripheral blood progenitor cells performs in different ways among transplantation centers. forceful mobilization schedules are comprised of growth factor alone, chemotherapy along with growth factor and also, a newly combination of novel agent such as plerixafor with any...

background: despite recent advances in mobilization techniques, a considerable portion of patients fail to mobilize sufficient number of cells for successful autologous stem cell transplantation. there are several studies available that have demonstrated enhanced mobilization of endothelial progenitor cells with atorvastatin. therefore, this prospective trial was conducted to evaluate the mobil...

hematopoietic stem/progenitor cells (hspcs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. interacting factors such as stromal derived factor-1/cxcr4, very late antigen-4/vascular cell adhesion molecule-1, lymphocyte function-associated antigen-1/ intercellular adhesion molec...

background: more than 36 % of the total population of iran consists of young people aged 15 to 25 yr. recent studies show that this age group has the highest rate of serious health problems. youth participatory studies on youth health priority have shown that mental health is one of the most important priorities in youth health. aim to assessing the mental health needs of youth we conducted a p...

Heat-induced diffusion of nucleosomes along DNA is an experimentally well-studied phenomenon, presumably induced by twist defects that propagate through the wrapped DNA portion. The diffusion constant depends dramatically on the local mechanical properties of the DNA and the presence of DNA-binding ligands. This has been quantitatively understood by a stochastic three-state model. Future experi...

Objectives: Despite numerous studies, having the best outcome is challenging after flexor tendon repairs in zone 2. This study were done to test the hypothesis that immediate postoperative active mobilization will achieve similar outcomes to passive mobilization. Methods: Fifty fingers in 38 patients with flexor tendon repair in zone 2 were enrolled in this trial. The patients randomly assig...

With nucleosomes being tightly associated with the majority of eukaryotic DNA, it is essential that mechanisms are in place that can move nucleosomes 'out of the way'. A focus of current research comprises chromatin remodeling complexes, which are ATP-consuming protein complexes that, for example, pull or push nucleosomes along DNA. The precise mechanisms used by those complexes are not yet und...

Zymomonas mobilis is a natural ethanologen with many desirable industrial biocatalyst characteristics. In this review, we will discuss work to develop Z. mobilis as a model system for biofuel production from the perspectives of substrate utilization, development for industrial robustness, potential product spectrum, strain evaluation and fermentation strategies. This review also encompasses per...

background: knee osteoarthritis is one of the most common disabilities, which may lead to some limitations in physical activity. this study aimed to evaluation of grade one mobilization in improvement of physical function. methods: in this single blind clinical trial with a randomized sampling method, 30 patients of grade two or three, knee osteoarthritis were assigned into three groups: group ...