نتایج جستجو برای Modification

تعداد نتایج: 86422  

Journal: :Circulation research 2013
Xuejun Wang, J Scott Pattison, Huabo Su,

Protein quality control functions to minimize the level and toxicity of misfolded proteins in the cell. Protein quality control is performed by intricate collaboration among chaperones and target protein degradation. The latter is performed primarily by the ubiquitin-proteasome system and perhaps autophagy. Terminally misfolded proteins that are not timely removed tend to form aggregates. Their...

Journal: :The Journal of antibiotics 1988
P F Wiley, D W Elrod, D E Harper,

Fifteen 3-substituted analogues of steffimycin B (1) have been synthesized and their activity against P388 murine leukemia has been determined. Three of these were substantially more active than the parent compound.

Journal: :Chemical communications 2016
Manuel Jäger, Adriaan J Minnaard,

Selective modification of unprotected carbohydrates is difficult due to the similar reactivity of the hydroxyl groups. In carbohydrate synthesis, therefore, even straightforward transformations often require multiple synthetic steps. The development of selective methods for carbohydrate modification is consequently highly desired. This review describes the methods for the regio- and chemoselect...

Journal: :Nano letters 2007
Michael Nolan, Sean O'Callaghan, Giorgos Fagas, James C Greer, Thomas Frauenheim,

Band gap modification for small-diameter (approximately 1 nm) silicon nanowires resulting from the use of different species for surface termination is investigated by density functional theory calculations. Because of quantum confinement, small-diameter wires exhibit a direct band gap that increases as the wire diameter narrows, irrespective of surface termination. This effect has been observed...

Journal: :Cell 2014
Manfred Schmid, Torben Heick Jensen,

RNA polymerase II generates a diverse set of RNA transcripts, including mRNA, miRNA, lncRNA, and sn(o)RNA. These transcripts are modified and processed in the nucleus by a particular set of enzymes, as illustrated in this SnapShot.

Journal: :Trends in genetics : TIG 2011
Steven Henikoff, Ali Shilatifard,

Histone modifications are key components of chromatin packaging but whether they constitute a 'code' has been contested. We believe that the central issue is causality: are histone modifications responsible for differences between chromatin states, or are differences in modifications mostly consequences of dynamic processes, such as transcription and nucleosome remodeling? We find that inferenc...

The suitability of three vapor deposition techniques for pore size modification was evaluated using polycarbonate track etched membranes as model supports. A feature scale model was employed to predict the pore geometry after modification and the resulting pure water flux. Physical vapor deposition (PVD) and pulsed plasma-enhanced chemical vapor deposition (PECVD), naturally, form asymmetric na...

Ali Nemati, Mehran Solati-Hashjin, Roxana Family, Shahram Namjoy Nik,

Background: Titanium (Ti) implants are commonly coated with hydroxyapatite (HA). However, HA has some disadvantages such as brittleness, low tensile strength and fracture toughness. It is desirable to combine the excellent mechanical properties of ZrO2 and the chemical inertness of Al2O3 with respect to the purpose of this project which was coating Ti implants with HA-ZrO2-Al2O3 to modify the s...

The creation of modified layer on metal surfaces using new methods is one of the procedures in surface engineering which can improve the surface mechanical properties. The electrical discharge process is a new method that can form a modified layer on the metal surfaces. This study aims to improve of pure aluminum surface properties through Electrical Discharge process with Monel 400 electrode. ...

This paper presents design modification to the existing standard wheelchair by incorporating an improved propulsion system and also braking and tilting systems that allow its full control with only one hand. The proposed design has the propulsion system with a chain drive powered through a four-bar linkage driven by the main handle. The desired direction of motion is obtained by moving the leve...

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