the objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (ir) and modified release (mr) tablets. the experiment included rats with both normoglyceamia and streptozocin (stz)-induced hyperglyceamia. several mr formulations were designed and in vitro drug release profile was assessed by a dissolution test. for the fur...

(Quality). Guideline on quality of oral modified release products

statement of problem: since the fluoride releases from materials with the property of releasing fluoride are decreasing gradually, it seems that probably the material rechargeability is more important than their long-term fluoride release. purpose: the objective of this study was to asses the fluoride release and rechargeability of 2 types of fluoride releasing restorative materials, a resin mo...

to investigate and compare the amount of fluoride release of conventional, resin modified and nanofilled resin modified glass ionomer cements.tablets of glass-ionomer cements were immersed in deionized water and incubated at 37°c. after 1, 2, 7, 15 and 30 days, fluoride ion was measured under normal atmospheric conditions by fluoride ion selective electrode. buffer (tisab ii) was used to decomp...

the purpose of this study was to investigate the effect of additives, poly(ethylene glycol) (peg) 1450, poloxamer 407, polyvinyl alcohol (pva) and sodium chloride in order to improve physico-chemical characteristics, encapsulation efficiency and in vitro release of bovine serum albumin, form poly(d,l-lactic-co-glycolic acid) (plga) microparticles prepared by the w/o/w solvent evaporation method...

the first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using peg 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. the second objective was to apply the modified solvent method for preparation of sustained release ...

      The first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using PEG 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. The second objective was to apply the modified solvent method for preparation of sustained re...