نتایج جستجو برای: Molecular Farming

تعداد نتایج: 659715  

Journal: :progress in biological sciences 2012
seyed mojtaba ghiasi ali-hatef salmanian ali sharafi ruhollah kazemi mahya jafari

the main aim of this study was to obtain the crimean-congo hemorrhagic fever virus (cchfv) glycoprotein, through either stable transgenic plants or using a transient expression system, and determine the yield, quality and finally the immunogenicity of the plant-made cchfv glycoprotein in a mouse model. we designed and synthesized a codon-optimized g1/g2 gene from the g1 and g2 parts of the cchf...

Journal: :iranian journal of pharmaceutical research 0
hamid reza heidari department of pharmaceutical biotechnology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran mojgan bandehpour cellular and molecular biology research center, shahid beheshti university of medical sciences, tehran, iran department of biotechnology, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran hossein vahidi department of pharmaceutical biotechnology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran jaleh barar research centre for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran bahram kazemi shahid beheshti university of medical sciences hossein naderi-manesh department of biophysics, faculty of biological sciences, tarbiat modares university, tehran, iran

molecular farming has been considered as a secure and economical approach for production of biopharmaceuticals. human tnf related apoptosis inducing ligand (trail) as a promising biopharmaceutical candidate has been produced in different expression hosts. however, little attention has been paid to molecular farming of the trail in spite of numerous advantages of plant expression systems. theref...

Journal: :jundishapur journal of natural pharmaceutical products 0
shahrzad ahangarzadeh department of agricultural biotechnology, university of agriculture and natural resources, ahvaz, ir iran; department of cellular and molecular biology research center, shahid beheshti university of medical sciences, tehran, ir iran mohammad hosein daneshvar department of agricultural biotechnology, university of agriculture and natural resources, ahvaz, ir iran hamid rajabi-memari department of agronomy and plant breeding, shahid chamran university, ahvaz, ir iran; department of agronomy and plant breeding, shahid chamran university, ahvaz, ir iran , +98-02123872552 hamid galehdari department of genetics, shahid chamran university, ahvaz, ir iran khalil alamisaied department of agricultural biotechnology, university of agriculture and natural resources, ahvaz, ir iran

background molecular farming is the production of important recombinant proteins in transgenic organisms on an agricultural scale. interferons are proteins with antiviral and antitumor activities and can be used for viral infections and cancers treatments. objectives this study reports the transformation of inf α2b gene in tobacco plant for the first time in iran. materials and methods interfer...

Journal: :Critical reviews in biotechnology 2008
Pervin Basaran Emilio Rodríguez-Cerezo

Production of foreign molecules in transgenic plants is anticipated to be an alternative to already established, microbial or animal expression systems with lower production costs. This article reviews the different technologies and approaches currently used to produce economically interesting molecules in plants or plant cell cultures, to evaluate their technical feasibility and economic impli...

Journal: :Trends in plant science 2001
H Daniell S J Streatfield K Wycoff

The use of plants for medicinal purposes dates back thousands of years but genetic engineering of plants to produce desired biopharmaceuticals is much more recent. As the demand for biopharmaceuticals is expected to increase, it would be wise to ensure that they will be available in significantly larger amounts, on a cost-effective basis. Currently, the cost of biopharmaceuticals limits their a...

2016
Nicola Weichert Valeska Hauptmann Christine Helmold Udo Conrad

Seeds enable plants to germinate and to grow in situations of limited availability of nutrients. The stable storage of different seed proteins is a remarkable presumption for successful germination and growth. These strategies have been adapted and used in several molecular farming projects. In this study, we explore the benefits of seed-based expression to produce the high molecular weight spi...

2014
Kafeel AHMAD

Ahmad K. (2014): Molecular farming: strategies, expression systems and bio-safety considerations. Czech J. Genet. Plant Breed., 50: 1–10. Molecular farming is an experimental application of biotechnology that involves the genetic modification of crops for the production of proteins and chemicals for medicinal and commercial purposes. The vast majority in the developing world cannot afford the h...

Journal: :Biotechnology advances 2011
Olawole O Obembe Jacob O Popoola Sadhu Leelavathi Siva V Reddy

Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are engineered to produce recombinant pharmaceutical and industrial proteins in large quantities. As an emerging subdivision of the biopharmaceutical industry, PMF is still trying to gain comparable social acceptance as the already established production systems that produce these high valued proteins in microbia...

Ali Sharafi Ali-Hatef Salmanian Mahya Jafari Ruhollah Kazemi Sadegh Chinikar Sedighe Zakeri Seyed Mojtaba Ghiasi

The main aim of this study was to obtain the Crimean-Congo hemorrhagic fever virus (CCHFV) glycoprotein, through either stable transgenic plants or using a transient expression system, and determine the yield, quality and finally the immunogenicity of the plant-made CCHFV glycoprotein in a mouse model. We designed and synthesized a codon-optimized G1/G2 gene from the G1 and G2 parts of the CCHF...

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