نتایج جستجو برای: Molt-4

تعداد نتایج: 1304747  

2013
Fu-Yuan Shih Tsung-Hung Chen Mei-Chin Lu Wu-Fu Chen Zhi-Hong Wen Yueh-Hsiung Kuo Ping-Jyun Sung

Two new eunicellin-based diterpenoids, cladieunicellins K (1) and L (2), were isolated from an octocoral Cladiella sp. The structures of 1 and 2 were elucidated by spectroscopic methods and 2 exhibited moderate cytotoxicity towards the MOLT-4 human leukemia.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1992
Y K Shimizu A Iwamoto M Hijikata R H Purcell H Yoshikura

A human T-cell line, MOLT-4, either uninfected or infected with murine retroviruses, was tested for its susceptibility to hepatitis C virus (HCV) infection. The cell cultures were inoculated with a serum containing HCV and then examined for the presence of viral sequences by cDNA/PCR. In murine retrovirus-infected MOLT-4 (MOLT-4 Ma) cells, intracellular minus-strand viral RNA, a putative replic...

Journal: :BioTechniques 2002
Maureen Thornton Kathryn Leigh Eward Charles E Helmstetter

A method is describedforproducing sizable quantities of synchronously dividing, minimally disturbed mammalian cells. Cultures were grown immobilized on surfaces such that cell division within the population resulted in the continuous release of synchronous newborn cells. As judged by the quality and duration of synchronous growth, cell size distributions, and DNA compositions, newborn mouse L12...

Background: β-Blockers have shown considerable cytotoxic, anti-tumor and anti-angiogenic effects. Metoprolol, a β-Blocker with anti-inflammation, anti-tumor and anti-angiogenic properties has been widely used for treatment of some cardiovascular diseases such as angina, hypertension, heart failure and myocardial infraction. Limited data exist about the cytotoxic effects of metoprolol on human c...

Background: Pregabalin, a selective inhibitor of voltage dependent calcium channels has been used for treatment of epilepsy, fibromyalgia, generalized anxiety disorder and especially neuropathic pains. The anti-inflammatory properties of pregabalin in some pathologic conditions like orofacial pain and streptozotocin-induced diabetic mice have been reported. Effectiveness of pregabalin in treatm...

Journal: :Blood 1988
J M Greenberg R Gonzalez-Sarmiento D C Arthur C W Wilkowski B J Streifel J H Kersey

Molt-3 and Molt-4 are T-cell lines originally derived in 1971 from a patient with T-cell acute lymphoblastic leukemia. An unusual T-cell antigen receptor gamma-chain gene (T-gamma) rearrangement detected by Southern blot analysis of Molt-4 prompted an in-depth study of the immunophenotype and karyotype of both cell lines. Molt-3 and Molt-4 had immunophenotypic characteristics of thymocytes with...

Background and Objective: Carvedilol, a non-specific β-blocker, has been used for treatment of hypertension, stroke and congestive heart failure. The therapeutic effects of β blockers in cancer patients have been shown. Carvedilol has considerable anti-inflammatory, anti-tumor and anti-angiogenic properties. In this study, the effects of carvedilol on proliferation of human U937 and Molt-4 leuk...

2017
Rouba Hage-Sleiman Hisham Bahmad Hadile Kobeissy Zeinab Dakdouk Firas Kobeissy Ghassan Dbaibo

Molt-4 leukemia cells undergo p53-dependent apoptosis accompanied by accumulation of de novo ceramide after 14 hours of γ-irradiation. In order to identify the potential mediators involved in ceramide accumulation and the cell death response, differentially expressed genes were identified by Affymetrix Microarray Analysis. Molt-4-LXSN cells, expressing wild type p53, and p53-deficient Molt-4-E6...

Journal: :Nucleic acids research 1994
H Nakashima Y Shoji S G Kim J Shimada Y Mizushima M Ito N Yamamoto H Takaku

Phosphorothioate antisense oligodeoxynucleotide against HIV-1 rev (S-ODN-rev) inhibits virus-induced cytopathic effects (CPE) in acute infection and inhibits the expression of HIV-1 core protein, p24, in chronically infected cells in vitro. HIV-1 reverse transcriptase activity was not affected by S-ODN-rev at the high concentrations of 5-25 microM, which were 250-1250 times higher than the conc...

2011
Xin Huang Qi Shen Si Chen Shaohua Chen Lijian Yang Jianyu Weng Xin Du Piotr Grabarczyk Grzegorz K Przybylski Christian A Schmidt Yangqiu Li

BACKGROUND Downregulation of the B-cell chronic lymphocytic leukemia (CLL)/lymphoma11B (BCL11B) gene by small interfering RNA (siRNA) leads to growth inhibition and apoptosis of the human T-cell acute lymphoblastic leukemia (T-ALL) cell line Molt-4. To further characterize the molecular mechanism, a global gene expression profile of BCL11B-siRNA -treated Molt-4 cells was established. The expres...

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