The possibilities of jow injection analysis for the on-line monitoring of dissolution tests are illustrated by using a very straightforward manifold to monitor tablets of ascorbic acid dissolving at different rates. The dissolution kinetics can be monitored at an adequate samplingfrequency as the method allows up to 90 samples to be processed per hour. Flow Injection Analysis (FIA) has proved t...

Platinum stability: Dissolution of Pt, which is one major degradation mechanism in, for example, hydrogen/air fuel cells, was monitored under potentiodynamic and potentiostatic conditions. The highly sensitive and time-resolving dissolution monitoring enables the distinction between anodic and cathodic dissolution processes during potential transient and chronoamperometric experiments, and the ...

objective(s): this paper describes a selective and sensitive biosensor based on the dissolution and aggregation of aptamer wrapped single-walled carbon nanotubes. we report on the direct detection of aptamer–cocaine interactions, namely between a dna aptamer and cocaine molecules based on near-infrared absorption at λ807. materials and methods: first a dna aptamer recognizing cocaine was non-co...

The solid-state form of an active pharmaceutical ingredient (API) in an oral dosage form plays an important role in determining the dissolution rate of the API. As the solid-state form can change during dissolution, there is a need to monitor the oral dosage form during dissolution testing. Coherent anti-Stokes Raman scattering (CARS) microscopy provides rapid, spectrally selective imaging to m...

Traditional pharmaceutical dissolution tests determine the amount of drug dissolved over time by measuring drug content in the dissolution medium. This method provides little direct information about what is happening on the surface of the dissolving tablet. As the tablet surface composition and structure can change during dissolution, it is essential to monitor it during dissolution testing. I...

UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug concentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current instrumentation and principles of analysis. Pharmaceutical applications of UV imaging are ...

Introduction: Fiber optic technology for dissolution testing has been a topic of interest for many researchers for some years. Josefson, Johansson, and Tortensson 1 published early research in this field in 1988. They explored the feasibility of using UV fiber optics for in-situ dissolution and to overcome sample turbidity interference without filtration. In 1993, Brown and Lin 2 used a single ...

Electrospun fiber mats are currently gaining attention as advanced drug delivery systems. Dissolution testing for such systems is generally performed in small vials by immersing the fiber mats in buffered solutions. Defined aliquots of dissolution medium are withdrawn at predefined time points, and the dissolved drug is quantified. However, this procedure is associated with several drawbacks. T...

Objective(s): This paper describes a selective and sensitive biosensor based on the dissolution and aggregation of aptamer wrapped single-walled carbon nanotubes. We report on the direct detection of aptamer–cocaine interactions, namely between a DNA aptamer and cocaine molecules based on near-infrared absorption at λ807. Materials and Methods: First a DNA aptamer recognizing cocaine was non-co...