monoamine oxidase (ec, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. abnormal action of the monoamine oxidase b has been associated with neurological dysfunctions including parkinson´s disorder. monoamine oxidase b inhibitors divulged that these agents were effective in the therapeutic management of parkinson's disease. understanding the interaction of...

When rat liver mitochondria are treated with the phospholipase A2 isolated from Naja naja venom in amounts sufficient to cause about 70% loss of mitochondrial phospholipids, both of the monoamine oxidase isozymes monoamine oxidase A and monoamine oxidase B are reduced in activity. With both monoamine oxidases, phospholipase treatment affects the enzyme’s affinity for the amine substrates rather...

conclusions the obtained results confirm some previous studies regardinga gender specific association of maoa gene with the bipolar disorder. results significant associations were observed regarding maoa-ca (p = 0.016) and maoa-vntr (p = 0.004) polymorphisms in the bipolar females. there was no association between maoa-rflp and bipolar disorder. patients and methods this study is a case-control...

abstract in the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from talaromyces sp. lgt-2, an endophytic fungus from tripterygium wilfordi. their structures were determined based on nmr and esi-ms spectral data, as well as comparing with previous literature data. this is the first report of the isolation ...

microcantilevers (mcls) are cost-effective and highly sensitive devices for biodetection. adsorption of specific analytes on the microcantilever surface causes the bending of mcl through changing of the surface characteristics. these new bioprobes designed in a way that one side of the microcantilever surface is coated with a selective receptor that absorbs particular molecules. after surface a...

To develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the HPLC method and a new substrate was used to develop a peroxidase-linked spectrophotometric assay. 4-(Trifluoromethyl) benzylamine (11) was proved to be an exc...

The possibility that genetically determined abnormalities in the monoamine oxidase of certain central nervous system aminergic neurones may play a part in the pathology of Huntington's chorea was investigated using human platelet monoamine oxidase. Significantly elevated monoamine oxidase activity was found in male patients compared to control subjects suggesting this may be a screening test fo...

3-Amino-1-phenylprop-1-ene (cinnamylamine) and some derivatives were examined as substrates for monoamine oxidases A and B in mitochondria. All of the amines examined were readily oxidized by monoamine oxidase B but much less readily by monoamine oxidase A. E-Cinnamylamine was found to have Km 0.025 mM and Vmax. 3.9 nmol/min per mg of mitochondrial protein. Corresponding values with monoamine o...

The nature of the prosthetic groups of monoamine oxidase has been the subject of much conjecture, and definitive experimental results have not been obtained. The results of Tabor et al. (1) suggest that pyridoxal phosphate may be the coenzyme of the enzyme, and Gorkin and Romanova (2) have suggested that the enzyme is a metalloenzyme. Others (3, 4) have proposed that monoamine oxidase is a flav...