m-Phthalic diamide-linked zinc bisporphyrinates have been developed as chirality probes for monoamines. They are capable of determining the absolute configuration of monoamines and distinguishing between alkyl and aryl substituents of chiral monoamines. Our studies suggest that steric interactions play critical roles in the molecular recognition process.

The vast majority of illicit stimulants act at monoaminergic systems, causing both psychostimulant and adverse effects. Stimulants can interact as substrates or antagonists the nerve terminal monoamine transporter that mediates reuptake monoamines across synaptic membrane vesicular (VMAT‐2) storage in vesicles. directly presynaptic postsynaptic receptors for have indirect monoamine‐mimetic acti...

BACKGROUND The involvement of biogenic monoamines in early ('preneural') embryogenesis has been well documented in lower vertebrates, but much less information is available about the role of these molecules in the earliest stages of development in mammals, including humans. METHODS Databases (PubMed, ISI Web of Knowledge and Scopus) were searched for studies relating to biogenic monoamines fu...

En France, on compte environ 5,5 millions de Français souffrant d’épisodes dépressifs majeurs, soit 8 % de la population française. L’objectif pharmacologique pour l’ensemble des antidépresseurs proposés à ce jour aux cliniciens était d’augmenter la concentration cérébrale en monoamines. Pour ce faire, trois mécanismes principaux sont recherchés : un mécanisme d’inhibition enzymatique de la dég...

The monoaminergic neurotransmitters dopamine, noradrenaline, and serotonin are pivotal actors of the interplay between nervous immune system due to their ability binding cell-receptors both systems, crucially regulating function within central periphery. As monoamines dysfunctional in many neurological psychiatric diseases, they have been successfully used as pharmacological targets. Multiple s...

Bath application of monoamines is a potent method for evoking locomotor activity in neonatal rats and mice. Monoamines also promote functional recovery in adult animals with spinal cord injuries by activating spinal cord networks. However, the mechanisms of their actions on spinal networks are largely unknown. In this study, we tested the hypothesis that monoamines establish rostrocaudal gradie...

Psychiatric disorders induced by social stress have suggested that monoamines play key roles in a whole brain network. To research an environmentally dependent neural network development of social psychology, we report our model animal study of peer-social behavior learning by screening the relevant monoamines in various brain regions in the light of social brain network. We have originally dev...

Objective(s): Systemic and intracerebroventricular (ICV) injection of insulin possess analgesic effects. The raphe magnus nucleus (RMN) is part of the endogenous analgesia system. The objective of the present study was to evaluate the effects of ICV injection of insulin on the levels of monoamines and their related metabolites in the RMN during the formalin test in non...

Biogenic monoamines (catecholamines, indoleamines and histamine) are evolutionary old and important modulators of long-lasting changes in the functional state of cells. They are found in many protozoans and in almost all metazoans. Monoamines preserve their evolutionary old functions (first of all being intracellular signals and later hormones and growth factors) even in those animals in which ...