the armadillo could be considered as an experimental model for leprosy studies. mycobacterium leprae main host cells are macrophages and schwann cells. however, endocytosis and germicidal activities of armadillo macrophages and monocytes have not yet been evaluated. the aim of this research was to evaluate endocytosis and nbt-reduction activities of monocyte-derived macrophages (mdm) and monocy...

The present study was conducted to quantify and compare TLR2 (toll-like receptor 2) activity in monocyte-derived macrophages of zebu (Tharparkar) and crossbred (Holstein-Friesian × Jersey × Brown Swiss × Hariana) cattle. The cells were either induced with Pam3CSK4 or kept as control. The TLR2 activity was quantified in terms of IκB-α inhibitory subunit (NFKBIA) messenger RNA (mRNA) copies...

human peripheral blood monocytes (hpbm) were cultured in the absence of human serum and were converted into a state exhibiting a high accessory function expressed by their ability of supporting lymphocyte proliferation. after a prolonged culture in serum free media the monocyte derived cells were highly viable, increased in size and developed veils and dendritiform elongatio'l1s. paralleli...

Human peripheral blood monocytes (HPBM) were cultured in the absence of human serum and were converted into a state exhibiting a high accessory function expressed by their ability of supporting lymphocyte proliferation. After a prolonged culture in serum free media the monocyte derived cells were highly viable, increased in size and developed veils and dendritiform elongatio'l1s. Paralleli...

The armadillo could be considered as an experimental model for leprosy studies. Mycobacterium leprae main host cells are macrophages and Schwann cells. However, endocytosis and germicidal activities of armadillo macrophages and monocytes have not yet been evaluated. The aim of this research was to evaluate endocytosis and NBT-reduction activities of monocyte-derived macrophages (MDM) and monocy...

Abstract Helminth infection conditions lung macrophages in the long term, but little is known about how helminths affect macrophage responses to respiratory viral coinfection. Experimental helminth of BALB/c and C57BL/6 mice revealed an increased type 2 airway inflammation that was associated with pronounced phenotypic changes macrophages. These consist a disappearance reaction SiglecF+ alveola...

Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the lung ameliorated lung fibrosis, whereas tissue-resident alveolar macrophages did not contribute to fibrosis. Using transcriptomic profiling of flow-sorted cell...

Naomi McGovern, Andreas Schlitzer, Merry Gunawan, Laura Jardine, Amanda Shin, Elizabeth Poyner, Kile Green, Rachel Dickinson, Xiao-nong Wang, Donovan Low, Katie Best, Samuel Covins, Paul Milne, Sarah Pagan, Khadija Aljefri, Martin Windebank, Diego Miranda-Saavedra, Anis Larbi, Pavandip Singh Wasan, Duan Kaibo, Michael Poidinger, Venetia Bigley, Florent Ginhoux, Matthew Collin,* and Muzlifah Han...

Macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains are able to grow to high titers in human monocyte-derived macrophages. However, it was recently reported that cellular protein SAMHD1 restricts HIV-1 replication in human cells of the myeloid lineage, including monocyte-derived macrophages. Here we show that degradation of SAMHD1 in monocyte-derived macrophages was associated...