A new stability-indicating RP-HPLC method was developed for the simultaneous determination of fexofenadine hydrochloride and montelukast in combined dosage form, using a Aligent, Zorbax (Make: 150 mmx4.6 mm I.D; particle size 5μm and a mobile phase composed of phospahte buffer (pH 4.0): Acetonitile (60:40 v/v) at a flow rate of 1.0mL/min. The retention times of fexofenadine hydrochloride and mo...

A simple, specific, accurate, and stability-indicating reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of montelukast and fexofenadine hydrochloride, using a Lichrospher(®) 100, RP-18e column and a mobile phase composed of methanol:0.1% o-phosphoric acid (90:10 v/v), pH 6.8. The retention times of montelukast and fexofenadine hydroc...

A simple, accurate, economical and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the determination of montelukast sodium and fexofenadine hydrochloride in bulk and pharmaceutical formulations. The separation was achieved on a phenomenex C column (150 × 4.6 mm i.d, particle size of 5μ) using a mixture of 0.1M potassium dihydro...

OBJECTIVE It is well-known that number of drugs may interfere with wheal reactions in skin prick test. However, the effect of long-term use of montelukast, a cystenil leukotriene receptor antagonist, on skin prick test hasn't been full elucidated. The aim of present study was to demonstrate the effect of montelukast on skin prick tests (SPT). METHODS This is a single-center, randomized, doubl...

A previously healthy 8-year old boy was seen for a second opinion regarding a 1-year history of urticaria. The initial onset of generalized urticaria was noted 30 minutes after a dose of fexofenadine for seasonal allergy symptoms. He had tolerated fexofenadine in previous pollen seasons without any complications. Since onset, he has had daily generalized urticaria. After 2 months of symptoms de...

Reported is a case of a 39-year-old male who was diagnosed with exercise-induced anaphylaxis (EIA). He was initially treated prophylactically with fexofenadine, montelukast, and ranitidine. He also used an epinephrine autoinjector as needed. He was refractory to these medications and continued to have episodes of EIA. He was then started on a trial of omalizumab, an immunoglobulin E monoclonal ...

Introduction: The goal of the current work is to create an RP-HPLC method for quantitative analysis Acebrophylline, Montelukast, and Fexofenadine in Pharmaceutical dosage form. Materials Methods: Chromatographic separation Montelukast was executed on Waters Alliance-e2695, by using Hyper clone 5μ BDS C18 130A (250 x 4.6mm) column mobile phase consisting Methanol: Ammonium formate adjusted pH-6 ...

OBJECTIVE Allergic rhinitis imposes a significant health and economic burden both on individuals and the healthcare system. Second-generation prescription antihistamines, levocetirizine, fexofenadine, and desloratadine, and the leukotriene receptor antagonist, montelukast, differ in their ability to relieve common rhinitis symptoms. The purpose of this study was to compare the cost-effectivenes...

Histamine is the main mediator of urticaria and H1-receptor antagonists represent the treatment of choice in all patients with chronic urticaria. Leukotriene receptor antagonists as montelukast have also been used in patients with chronic urticaria unresponsive to H1-antihistamines alone. We report a patient with chronic urticaria whose disease was paradoxically exacerbated by H1-antihistamines...