a 54 year old man with history of cardiomyopathy and chronic fibrillation first presented with bloody diarrhea. then during the assessment of his abnormal lab. data revealed cast nephropathy in renal biopsy, gamma peak in protein electrophoresis and fine lytic lesions in skull graphy. his bone marrow aspiration showed multiple myeloma and blood smear revealed plasma cell leukemia. our patient w...

introduction plasma cell dyscrasias are characterized by a monoclonal neoplastic proliferation of plasma cells. solitary bone plasmacytoma (sbp) is a local form of the disease with the vertebrae and long bones being the most frequently encountered sites. its prevalence in the maxillofacial area is extremely rare. case presentation a 70-year-old caucasian male patient was referred for the extrac...

Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical  pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia >11.5g/dl and 5) renal insufficiency. Non secretory multiple myeloma is a rare variant of the classic form of multi...

Extramedullary plasmacytoma occurs in 18% of patients with multiple myeloma. Laryngeal involvement in multiple myeloma is rare, and only a few cases have been reported. We present a case of a 44-year-old women with multiple myeloma who presented with stridor due to a mass involving the larynx which was initially proven to be plasmacytoma on biopsy. She had evidence of multiple myeloma of IgA la...

introduction: multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia, and hypercalcemia. the hyperviscosity syndrome is rare. cryoglobulins are immunoglubulins that precipitate in the cold temperature less than 37˚c. monoclonal cryoglobulins are associated with...

multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10% of all hematologic cancers. it is characterized by accumulation of clonal plasma cells, predominantly in the bone marrow. the prevalence of type 2 diabetes is increasing; therefore, it is expected that there will be an increase in the diagnosis of multiple myeloma with concomitant diabetes mellitus. the tre...

results of the 89 subjects, 53 were male and 36 females, aged 14 to 82 years. there was no significant difference between ebv seroprevalence in the patients with lymphoma and multiple myeloma, and the healthy subjects. conclusions the results of the current study indicated no relationship between latent ebv infection and lymphoma or multiple myeloma. however, further studies with larger sample ...

multiple myeloma (mm) is characterized by progressive proliferation of malignant plasma cells, usually initiating in the bone marrow. mm can affect any organ; a total of 7 - 18% of patients with mm demonstrate extramedullary involvement at diagnosis. non-secretory multiple myeloma (nsmm) is a rare variant that accounts for 1 - 5% of all cases of multiple myeloma. the disease is characterized by...

involvement of the peripheral nervous system is one of the complications of multiple myeloma with a varying incidence of clinical and subclinical neuropathy in different studies. as most of the patients with multiple myeloma suffer from generalized systemic symptoms such as malaise, bone and low back pain, the clinical clues to the diagnosis of the neuropathy in its initial stages could be igno...