KEYWORDS antiviral agents; chemotherapy; polyamidoamine; multivalency.

Addition of mycophenolic acid to cultures of HL-60 cells results in a decreased cellular level of guanine nucleotides and the induction of cell differentiation. During the early stages of this induction, steady-state levels of cellular IMP dehydrogenase (IMPDH), messenger RNA (mRNA), and protein are increased, perhaps because of cellular compensation for the inhibition of IMPDH activity. The su...

The aqueous solubility of solid-state pharmaceuticals can often be enhanced by cocrystallization with a coformer to create binary cocrystal preferred physical properties. Greater understanding the internal and external forces that dictate molecular structure intermolecular packing arrangements enables more efficient design new cocrystals. Low-frequency (sub-200 cm−1) Raman spectroscopy experime...