background: the purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid (mpa) in iranian kidney transplant patients. methods: plasma mpa concentration of mycophenolate mofetile (mmf) 1 gram two times a day was measured in 21 iranian kidney transplant recipients receiving treatment. patients who entered the study had been transplanted for more than 3 months ...

immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. this variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. drug monitoring is widely practiced ...

n our laboratory in 4CS mice. (3) Mouse ascites hepatoma, MH134, was converted into ascitic form by Sato et al.*\ from a C3H/HeN mouse hapatoma induced after treatment with carbon tetrachloride by Andervont et al.5) It has been maintained in C3H/He mice with distinct strain specificity in tumor take in our laboratory. (4) Mouse ascites sarcoma, SR-C3H/He Th62, was originally induced with Schmid...

Several derivatives of mycophenolic acid (MA) were tested for their antitumor activity against leukemia L-1210 when administered orally and carbamoyl mycophenolic acid ethylester (CMAE) was selected as the most active antitumor agent in these tests. An oral administration of CMAE also inhibited the growth of Ehrlich solid carcinoma, NF sarcoma, myeloma X-5563 and sarcoma 180 in mice. In compari...

■ Efficient sample clean-up resulting in better analytical results and system robustness IN T RO DU C T IO N Mycophenolic acid is a drug that interferes with purine nucleotide synthesis required for the proliferative response of T and B cells. Measurement of drug levels in plasma can be performed by a variety of analytical methods including immunoassay, LC with UV detection, or LC/MS. LC/MS met...

OBJECTIVES We sought to develop a B-cell in vitro culture system and test B cells isolated from sensitized kidney recipients and healthy controls, and assess the effectiveness of proteasome inhibitors and mycophenolic acid on antibody secretion and cell apoptosis. MATERIALS AND METHODS CD19(+) B cells and CD19(+)CD27(+) memory B-cell subsets were detected from peripheral blood mononuclear cel...

Mycophenolic acid and virazole are inhibitors of inosinate dehydrogenase and produce growth inhibition and loss of viability in cultured munine lymphoma L5178Y cells. Treat ment with 1 @Mmycophenolic acid produced the following changes in concentrations of acid-soluble nucleotides: (a) guanosine tniphosphate decreased to less than 10% of con trol within 2 hr; (b) unidine triphosphate and cytidi...