Introduction: Differentiation of fibroblasts to myofibroblasts is an initial and very important event in tumor genesis. Myofibroblasts produce proteinases that stimulate invasion in cancers. Due to the more malignant potential of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC) , the aim of the present study was to compare myofibroblasts between OSCC and ...

Introduction:Calcifying odontogenic cyst (COC) is an odontogenic cyst that sometimes shows aggressive behavior, while dentigerous cyst (DC) always has a benign nonaggressive course. There are evidences that myofibroblasts are involved in invasion and their role in biologic behavior of odontogenic cysts has been less understood. So, the aim of the present study was to compare th...

background. the aim of this study was to investigate myofibroblast (mf) density in a broad spectrum of odontogenic cysts and tumors and the relation between the density of mfs and the clinical behavior of these lesions. methods. a total of 105 cases of odontogenic lesions, including unicystic ameloblastoma (uam), solid ameloblastoma (sa), odontogenic keratocyst (okc), dentigerous cyst (dc), rad...

Hypertrophic scars are a common complication of burn injury, yet there no medications to prevent their formation. Myofibroblasts, key cell involved in scar formation, resistant apoptosis. We have previously shown that hydroxypyridone anti-fungals can inhibit myofibroblast transformation scar-derived fibroblasts. This study aimed investigate if these drugs target established myofibroblasts. Prim...

We investigated the distribution of myofibroblasts and CD34-positive stromal cells in normal gallbladder and its pathological conditions (cholecystitis, n=25) using immunohistochemistry and in situ hybridization. In the wall of normal gallbladder, myofibroblasts were generally absent from all layers, but many CD34-positive stromal cells were observed in the connective tissue layer. In chronic c...

Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification with decreased alveolar number and increased airspace size. Formation of alveoli involves a process known as secondary septation triggered by myofibroblasts. This study investigated the underlying mechanisms of altered lung morphogenesis in a rat model of BPD induced by intra-amniotic injection of lipopolysaccharide (L...

PURPOSE To investigate the adhesion characteristics of corneal myofibroblasts in a cell culture model. METHODS Immunocytochemistry, immunoprecipitation, western blot analysis, and attachment assays were used to evaluate matrix adhesion characteristics of myofibroblasts. RESULTS Myofibroblasts, defined by their expression of the smooth muscle isoform of alpha-actin, were evaluated and compar...

Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ. The treatment options are inadequate and reflect the fact that signaling targets in myofibroblasts are unknown. Here we identify the hyperactive Lyn signaling in myofibroblasts of patients with chronic pancreatitis-ind...

BACKGROUND Myofibroblasts play a crucial role in tissue repair. The functional similarities and differences between myofibroblasts and fibroblasts are not fully understood because they have not been separately isolated from a living body. The purpose of this study was to establish a method for the direct isolation of myofibroblasts and fibroblasts from injured lungs by using fluorescence-activa...